Agomelatine facilitates positive versus negative affective processing in healthy volunteer models.
Agomelatine is a new antidepressant with a novel profile of pharmacological action. The clinical efficacy of agomelatine has been established in major depression, but its actions on emotional bias are unknown. Consequently, the current experimental study assessed the effect of agomelatine on emotion...
| Publicado en: | Journal of Psychopharmacology Vol. 25; no. 9; pp. 1159 - 1168 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Sage Publications Inc.
Sep2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104588599&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104588599 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02698811 3FD jtl: Journal of Psychopharmacology issn: 02698811 maglogo: Y pubinfo: dt: Sep2011 vid: 25 iid: 9 pid: 344 pub: Sage Publications Inc. place: Thousand Oaks, California artinfo: ui: 104588599 NLM20660010 2011319375 10.1177/0269881110376689 NLM20660010 104588599 ppf: 1159 ppct: 9 formats: tig: atl: Agomelatine facilitates positive versus negative affective processing in healthy volunteer models. aug: au: Harmer CJ de Bodinat C Dawson GR Dourish CT Waldenmaier L Adams S Cowen PJ Goodwin GM Harmer, Catherine J de Bodinat, Christian Dawson, Gerard R Dourish, Colin T Waldenmaier, Lara Adams, Sally Cowen, Philip J Goodwin, Guy M affil: Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK sug: subj: Acetic Acids Pharmacodynamics Affect Drug Effects Antidepressive Agents Pharmacodynamics Emotions Drug Effects Acetic Acids Administration and Dosage Adolescence Adult Antidepressive Agents Administration and Dosage Dose-Response Relationship, Drug Double-Blind Studies Drug Design Facial Expression Female Human Male Memory Drug Effects Reflex Drug Effects Young Adult Adolescent: 13-18 years Adult: 19-44 years Female Male ab: Agomelatine is a new antidepressant with a novel profile of pharmacological action. The clinical efficacy of agomelatine has been established in major depression, but its actions on emotional bias are unknown. Consequently, the current experimental study assessed the effect of agomelatine on emotional processing in healthy volunteers using an Emotional Test Battery shown to be sensitive to serotonin and noradrenaline reuptake inhibitors. Volunteers were randomized to receive placebo, 25 mg or 50 mg of agomelatine over a 7-day period in a double-blind parallel groups design. Emotional processing (n = 48) was assessed on the morning of day 8 using the Emotional Test Battery which included facial expression recognition, emotional memory, attentional visual probe and emotion-potentiated startle. Mood and subjective state were monitored before and during treatment. Agomelatine (25 mg) decreased subjective ratings of sadness, reduced recognition of sad facial expressions, improved positive affective memory and reduced the emotion-potentiated startle response. The results show that agomelatine has more selective effects on the processing of social facial cues than conventional antidepressants, which could contribute to less blunting of emotional experience. The study highlights the potential value of volunteer models in drug development for screening and profiling of novel antidepressants. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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