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Population pharmacokinetics of alcohol on Chinese subjects using breath measures.

Summary What is known and Objective: Alcohol is a widely used drug. Our objective was to examine alcohol pharmacokinetics in Chinese subjects through the breath measurement of blood alcohol concentration (BAC) to identify any measurable covariates that may help explain variability between subjects....

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Published in:Journal of Clinical Pharmacy & Therapeutics Vol. 36; no. 6; pp. 716 - 725
Main Authors: Yang, C. T., Fung, W. K., Tam, T. W. M.
Format: equations & formulas research tables/charts Journal Article
Published: Wiley-Blackwell Dec2011
Online Access:View this record in EBSCOhost
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        02694727
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      jtl: Journal of Clinical Pharmacy & Therapeutics
      issn: 02694727
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      dt: Dec2011
      vid: 36
      iid: 6
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        104591814
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        10.1111/j.1365-2710.2010.01226.x
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        atl: Population pharmacokinetics of alcohol on Chinese subjects using breath measures.
      aug:
        au:
          Yang, C. T.
          Fung, W. K.
          Tam, T. W. M.
        affil: Department of Statistics and Actuarial Science, The University of Hong Kong,
      sug:
        subj:
          Ethanol Pharmacokinetics
          Breath Tests Methods
          Human
          China
          Male
          Female
          Body Weight
          Sex Factors
          Ethanol Administration and Dosage
          Descriptive Statistics
          Data Analysis Software
          Male
          Female
      ab: Summary What is known and Objective: Alcohol is a widely used drug. Our objective was to examine alcohol pharmacokinetics in Chinese subjects through the breath measurement of blood alcohol concentration (BAC) to identify any measurable covariates that may help explain variability between subjects. Methods: Breath-alcohol measurements of 184 healthy Chinese subjects were collected. Compartmental models including one- and two-compartment process were examined. First-order kinetics was applied to model alcohol absorption and elimination phases. For the sake of simplicity, only the subject's body weight, sex and stomach condition were investigated as covariates in our random effects modelling. Results and Discussion: The body as a whole behaves as a single compartment, with the suggested one-compartment model being good enough to characterize the biological process. In line with other studies, food ingestion before/with the dose slowed down alcohol absorption into the central compartment. Female subjects exhibited a significantly higher BAC elimination rate than that of males. Body weight also contributed to the observed inter-subject variability in alcohol clearance. What is new and Conclusion: We present a model for estimating blood-alcohol levels from breath-alcohol measurements. The results of our study are useful particularly in relation to drink-driving prosecutions because of the routine use of breath-alcohol measurements as evidence in such cases through the world.
      pubtype: Academic Journal
      doctype:
        equations & formulas
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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