Endothelial factors after selective retrograde coronary venous bypass under different pressures.
Background: Selective retrograde coronary venous bypass (SRCVB) may be a promising treatment for patients with advanced coronary artery disease (CAD). The aim of this study is to investigate the effect of SRCVB on plasma endothelial factor levels in dog myocardial ischemic model, and explore the pos...
| Publicado en: | Scandinavian Cardiovascular Journal Vol. 45; no. 6; pp. 369 - 374 |
|---|---|
| Autores principales: | , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Dec2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104597307&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104597307 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14017431 2UX jtl: Scandinavian Cardiovascular Journal issn: 14017431 maglogo: Y pubinfo: dt: Dec2011 vid: 45 iid: 6 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104597307 NLM22070402 2011361537 10.3109/14017431.2011.616219 NLM22070402 104597307 ppf: 369 ppct: 5 formats: tig: atl: Endothelial factors after selective retrograde coronary venous bypass under different pressures. aug: au: Zhao Y Gu TX Zhang GW Shi EY Yu L Wang C Zhao, Ye Gu, Tian-Xiang Zhang, Guang-Wei Shi, En-Yi Yu, Lei Wang, Chun affil: Department of Cardiac Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China sug: subj: Epithelial Cells Metabolism Endothelins Blood Myocardial Ischemia Surgery Myocardial Revascularization Methods Nitric Oxide Blood Perfusion Methods Animals Aorta, Thoracic Surgery Biological Markers Blood Coronary Angiography Models, Biological Dogs Female Male Myocardial Ischemia Blood Myocardial Ischemia Pathology Myocardial Ischemia Radiography Pressure Saphenous Vein Transplantation Time Factors Veins Surgery Female Male ab: Background: Selective retrograde coronary venous bypass (SRCVB) may be a promising treatment for patients with advanced coronary artery disease (CAD). The aim of this study is to investigate the effect of SRCVB on plasma endothelial factor levels in dog myocardial ischemic model, and explore the possible mechanisms. Methods: 24 crossbreed dogs were randomly divided into three groups: (1) control group; (2) SRCVB group with 60 mmHg perfusion pressure; (3) SRCVB group with 90 mmHg perfusion pressure. The posterior descending coronary artery (PDA) was ligated in all groups, and SRCVB was performed in the last two groups. The levels of plasma nitric oxide (NO) and endothelin (ET) at different time points were determined in each group. In SRCVB groups, ink and imaging agent were injected to the heart through SVG graft for assessment of vein perfusion. Results: At the acute period, there were significant increase in the plasma levels of NO and decrease in ET in SRCVB 90 mmHg group compared with the control (P < 0. 01), and a further improvement were found in SRCVB 60 mmHg group (P < 0. 01). The ink or imaging agent was found in the myocardial tissue and flowed back to right atrium through contralateral coronary vein. Conclusions: SRCVB with low level of perfusion pressure could provide effective perfusion for ischemic myocardium and alleviate the myocardial endothelial cell injury. It may be a new therapeutic strategy for severe CAD. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|