European and North American lung cancer screening experience and implications for pulmonary nodule management.
The potential for low dose computed tomography (LDCT) to act as an effective tool in screening for lung cancer is currently the subject of several randomised control trials. It has recently been given prominence by interim results released by the North American National Lung Screening Trial (NLST)....
| Publicado en: | European Radiology Vol. 21; no. 12; pp. 2445 - 2455 |
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| Autores principales: | , , , |
| Formato: | review Journal Article |
| Publicado: |
Springer Nature
Dec2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104601636&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104601636 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Dec2011 vid: 21 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104601636 67224581 NLM21830100 2011375642 10.1007/s00330-011-2219-y NLM21830100 104601636 ppf: 2445 ppct: 10 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: European and North American lung cancer screening experience and implications for pulmonary nodule management. aug: au: Nair A Hansell DM Nair, Arjun Hansell, David M affil: Department of Radiology, St Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK sug: subj: Early Detection of Cancer Methods Lung Neoplasms Radiography Precancerous Conditions Radiography Radiation Dosage Tomography, X-Ray Computed Methods Europe Lung Neoplasms Epidemiology Lung Neoplasms Pathology Multicenter Studies North America Practice Guidelines Precancerous Conditions Epidemiology Precancerous Conditions Pathology Clinical Trials ab: The potential for low dose computed tomography (LDCT) to act as an effective tool in screening for lung cancer is currently the subject of several randomised control trials. It has recently been given prominence by interim results released by the North American National Lung Screening Trial (NLST). Several other trials assessing LDCT as a screening tool are currently underway in Europe, and are due to report their final results in the next few years. These include the NELSON, DLSCT, DANTE, ITALUNG, MILD and LUSI trials. Although slow to instigate a trial of its own, the UK Lung Screen (UKLS) trial will shortly commence. The knowledge gained from the newer trials has mostly reinforced and refined previous concepts that have formed the basis of existing nodule management guidelines. This article takes the opportunity to summarise the main aspects and initial results of the trials presently underway, assess the status of current collaborative efforts and the scope for future collaboration, and analyse observations from these studies that may usefully inform the management of the indeterminate pulmonary nodule. Key Points • Low dose CT screening for lung cancer is promising. • The effect of LDCT screening on mortality is still uncertain. • Several European randomised controlled trials for LDCT are underway. • The trials vary in methodology but most compare LDCT to no screening. • Preliminary results have reinforced existing nodule management concepts. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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