Successful implementation of image-guided radiation therapy quality assurance in the Trans Tasman Radiation Oncology Group 08.01 PROFIT Study.
Purpose: The quality assurance (QA) of image-guided radiation therapy (IGRT) within clinical trials is in its infancy, but its importance will continue to grow as IGRT becomes the standard of care. The purpose of this study was to demonstrate the feasibility of IGRT QA as part of the credentialing p...
| Publicado en: | International Journal of Radiation Oncology, Biology, Physics Vol. 81; no. 5; pp. 1576 - 1582 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Pergamon Press - An Imprint of Elsevier Science
Dec2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104603499&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104603499 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Dec2011 vid: 81 iid: 5 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 104603499 NLM21074334 2011378936 10.1016/j.ijrobp.2010.09.017 NLM21074334 104603499 ppf: 1576 ppct: 6 formats: tig: atl: Successful implementation of image-guided radiation therapy quality assurance in the Trans Tasman Radiation Oncology Group 08.01 PROFIT Study. aug: au: Middleton M Frantzis J Healy B Jones M Murry R Kron T Plank A Catton C Martin J Middleton, Mark Frantzis, Jim Healy, Brendan Jones, Mark Murry, Rebecca Kron, Tomas Plank, Ashley Catton, Charles Martin, Jarad affil: Radiation Oncology Queensland, St. Andrews Hospital, Toowoomba, Queensland, Australia sug: subj: Accreditation Standards Benchmarking Prostatic Neoplasms Radiotherapy Radiotherapy Equipment and Supplies Radiotherapy Standards Radiotherapy, Computer-Assisted Standards Australia Cancer Care Facilities Standards Human Male Ontario Pilot Studies Prostatic Neoplasms Radiography Quality Control (Technology) Radiation Oncology Standards Randomized Controlled Trials Male ab: Purpose: The quality assurance (QA) of image-guided radiation therapy (IGRT) within clinical trials is in its infancy, but its importance will continue to grow as IGRT becomes the standard of care. The purpose of this study was to demonstrate the feasibility of IGRT QA as part of the credentialing process for a clinical trial. Methods and Materials: As part of the accreditation process for a randomized trial in prostate cancer hypofraction, IGRT benchmarking across multiple sites was incorporated. Each participating site underwent IGRT credentialing via a site visit. In all centers, intraprostatic fiducials were used. A real-time assessment of analysis of IGRT was performed using Varian's Offline Review image analysis package. Two-dimensional (2D) kV and MV electronic portal imaging prostate patient datasets were used, consisting of 39 treatment verification images for 2D/2D comparison with the digitally reconstructed radiograph derived from the planning scan. The influence of differing sites, image modality, and observer experience on IGRT was then assessed. Results: Statistical analysis of the mean mismatch errors showed that IGRT analysis was performed uniformly regardless of institution, therapist seniority, or imaging modality across the three orthogonal planes. Conclusions: The IGRT component of clinical trials that include sophisticated planning and treatment protocols must undergo stringent QA. The IGRT technique of intraprostatic fiducials has been shown in the context of this trial to be undertaken in a uniform manner across Australia. Extending this concept to many sites with different equipment and IGRT experience will require a robust remote credentialing process. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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