Patient-focused endpoints in advanced cancer: Criterion-based validation of accelerometer-based activity monitoring.
Summary: Background & aims: Objective assessment of daily physical activity (PA) by body-worn accelerometers offers potential as a novel endpoint in the clinical management of advanced cancer patients. This study aimed to assess criterion-based validity of an accelerometer-based activity monitoring...
| Published in: | Clinical Nutrition Vol. 30; no. 6; pp. 812 - 822 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | equations & formulas research tables/charts Journal Article |
| Published: |
Elsevier B.V.
Dec2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104606226&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104606226 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02615614 8IC jtl: Clinical Nutrition issn: 02615614 maglogo: N pubinfo: dt: Dec2011 vid: 30 iid: 6 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 104606226 67548050 10.1016/j.clnu.2011.05.010 NLM21733604 104606226 ppf: 812 ppct: 10 formats: tig: atl: Patient-focused endpoints in advanced cancer: Criterion-based validation of accelerometer-based activity monitoring. aug: au: Skipworth, Richard J.E. Stene, Guro B. Dahele, Max Hendry, Paul O. Small, Alexandra C. Blum, David Kaasa, Stein Trottenberg, Peter Radbruch, Lukas Strasser, Florian Preston, Tom Fearon, Kenneth C.H. Helbostad, Jorunn L. affil: Clinical and Surgical Sciences (Surgery), University of Edinburgh, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, United Kingdom sug: subj: Physical Activity Evaluation Accelerometry Energy Metabolism Evaluation Human Validation Studies Inpatients Outpatients Norway Germany Switzerland Doubly Labeled Water Technique Data Collection Methods Accelerometers Videorecording Calorimetry Data Analysis Software T-Tests Pearson's Correlation Coefficient Post Hoc Analysis Adult Middle Age Aged Aged, 80 and Over Female Male P-Value Regression Adipose Tissue Funding Source Karnofsky Performance Status Clinical Assessment Tools Scales Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Aged, 80 & over Female Male ab: Summary: Background & aims: Objective assessment of daily physical activity (PA) by body-worn accelerometers offers potential as a novel endpoint in the clinical management of advanced cancer patients. This study aimed to assess criterion-based validity of an accelerometer-based activity monitoring system (AM-system), ActivPAL™, using two different methods. Methods: Advanced cancer in patients and outpatients (Karnofsky Performance Status (KPS) 40–100). ActivPAL™ measurements were validated against (i) observations and (ii) energy expenditure (EE) measured by 2-week doubly-labelled water (DLW) protocol. Results: Absolute errors for mean time spent in different body positions (<0.1%) and number of transfers (0%) were low. Step count error was significantly higher in patients with KPS 40–60 (non-self caring) compared to KPS 70–100 (self-caring) (33 vs. 24%, p = 0.006). Post-hoc mathematical analysis demonstrated that absolute errors for the mean energy expenditure of activity (EEA) (1.4%) and mean total EE (0.4%) were low, but agreement was also low. Conclusions: AM-systems provide valid estimates of body positions and transfers, but not step count, especially in non-self caring patients. ActivPAL™ can derive estimates of EE but there is considerable variability in results, which is consistent, in part, with the inaccuracy in step count. Further studies are required to assess the validity of different endpoints derived from AM-systems in advanced cancer patients. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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