The Relationship Between the Peroxisome Proliferator-Activated Receptor Gamma 2 Gene Polymorphism, Lipids and Adipokines in Patients with Major Depression.
Objective: Peroxisome proliferator-activated receptor gamma (PPAR?), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPAR? gene polymorphism, adipokines, lipids, and lipoproteins to the...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 31; no. 5; pp. 1065 - 1073 |
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| Main Authors: | , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Oct2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104607217&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104607217 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Oct2011 vid: 31 iid: 5 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104607217 2011384914 10.5336/medsci.2010-20010 104607217 ppf: 1065 ppct: 8 formats: fmt: @attributes: type: P tig: atl: The Relationship Between the Peroxisome Proliferator-Activated Receptor Gamma 2 Gene Polymorphism, Lipids and Adipokines in Patients with Major Depression. aug: au: Aliyazicioglu, Rezzan Deger, Orhan Kural, Birgül Vanizor Hocaoglu, Çiçek Çolak, Meltem Yücesan, Fulya Balaban sug: subj: Depression Familial and Genetic Lipids Polymorphism, Genetic Receptors, Cell Surface Academic Medical Centers Adult Case Control Studies Cholesterol Blood Descriptive Statistics DNA Analysis Enzyme-Linked Immunosorbent Assay Goodness of Fit Chi Square Test Human Lipoproteins, HDL Blood Lipoproteins, LDL Blood Mann-Whitney U Test Middle Age One-Way Analysis of Variance Polymerase Chain Reaction Post Hoc Analysis Sequence Analysis Triglycerides Blood Turkiye Unpaired T-Tests Adult: 19-44 years Middle Aged: 45-64 years ab: Objective: Peroxisome proliferator-activated receptor gamma (PPAR?), lipids, lipoproteins, and adipokines have recently been shown to be associated with psychiatric diseases. Our major aim is to investigate the contribution of the PPAR? gene polymorphism, adipokines, lipids, and lipoproteins to the development of major depression. Material and Methods: The frequency of Pro12Ala in exon 2 and C478T in exon 6 of the PPAR? gene, lipids and adipokines in major depression (n = 78) and control subjects (n= 64) were analyzed. Genotypes of PPAR? gene polymorphisms were examined. Serum leptin, adiponectin, and resistin were studied by enzyme-linked immunosorbent assay (ELISA). Serum apo A1, apo B, and Lp(a) levels were determined by immunonephelometry. Serum total cholesterol, triglyceride, HDL-cholesterol and LDL-cholesterol levels were analyzed by enzymatic methods. Results: The genotypes of exon 2 and exon 6 distribution did not differ between the control subjects and patients with major depression. Frequencies of genotypes of Pro12Ala, and Ala12Ala in exon 2 in overweight and obese patients with major depression were higher than those of overweight and obese controls. C478T polymorphism was highest in overweight and obese patients with major depression. Pro12Ala and Ala12Ala genotypes in exon 2 of PPAR? gene in patients were found to be associated with triglyceride and HDL-cholesterol. There were significant differences regarding glucose, total cholesterol, LDL-cholesterol, apo B, Lp(a), adiponectin and resistin levels between patient and control subjects. Conclusion: PPAR? exon gene polymorphisms, alterations in lipid profile and adipokines may be associated with the development of major depression. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
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