Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients.
Objective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety ei...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 31; no. 5; pp. 1100 - 1106 |
|---|---|
| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Oct2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104607222&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104607222 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Oct2011 vid: 31 iid: 5 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104607222 2011385003 10.5336/medsci.2010-20470 104607222 ppf: 1100 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Evaluation of Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Type 1 Diabetes Mellitus Patients. aug: au: Gönül, Saban Özkagnici, Ahmet Öztürk, Banu Turgut Kerimoglu, Hürkan Sahin, Alparslan sug: subj: Diabetes Mellitus, Type 1 Complications Lasers Retina Tomography Methods Academic Medical Centers Adolescence Adult Analysis of Variance Case Control Studies Child Data Analysis Software Descriptive Statistics Diabetic Retinopathy Diagnosis Human Post Hoc Analysis Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years ab: Objective: To evaluate retinal nerve fiber layer (RNFL) thickness changes of type 1 diabetes mellitus (DM) patients with and without diabetic retinopathy (DR). Material and Methods: One hundred-eighteen patients with type 1 DM and 49 age-matched control subjects were enrolled in the study. Ninety eight of 118 diabetic patients with DR were assigned as group 1 and the remaining 20 patients without DR were labeled as group 20 (n= 98). The RNFL thickness of all subjects were measured using optical coherence tomography (OCT). Results: The study included 118 type 1 DM patients with a mean age of 18.77±8.80 years. The mean age of 49 subjects in the control group was 18.71 ± 5.72 (range 7-40) years.The mean RNFL thickness was 103.79 ± 6.45 ?m in the control group, 100.00 ± 11.93 ?m in group 1 and 85.59 ± 19.81 ?m in group 2. The decrease in group 2 was found statistically significant (p< 0.001). The mean RNFL thickness in the superior, nasal, inferior and temporal quadrants were less in group 1 compared to controls, however this data was not statistically significant (p= 0.274, p= 0.149, p= 0326, p= 0783, respectively). In group 2, the RNFL thickness revealed a statistically significant decrease in all quadrants (p< 0.001) except temporal quadrant (p= 0.396). The mean duration of DM was significantly longer in group 2 (153.80 ± 70.35) compared to group 1 (60.76 ± 50.41 months) (p< 0.001). However, there was no correlation between the RNFL thickness and the duration of DM. Conclusion: The RNFL thickness of patients with type 1 DM was found less compared to control subjects. This was more prominent in patients with established retinopathy (group 2). These findings suggested that the RNFL thickness measurement with the aid of OCT may be used as an adjunctive diagnostic tool for early diagnosis of DR. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Turkish refInfo: holdings: @attributes: islocal: N |
|---|