Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease.
Background: While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.Objective: To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using...
| Published in: | Pediatric Radiology Vol. 41; no. 12; pp. 1552 - 1559 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Springer Nature
Dec2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104607659&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104607659 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Dec2011 vid: 41 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104607659 NLM21785852 2011390877 10.1007/s00247-011-2186-0 NLM21785852 104607659 ppf: 1552 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease. aug: au: Dillman JR Ladino-Torres MF Adler J Dematos-Malliard V McHugh JB Khalatbari S Strouse PJ Dillman, Jonathan R Ladino-Torres, Maria F Adler, Jeremy DeMatos-Malliard, Vera McHugh, Jonathan B Khalatbari, Shokoufeh Strouse, Peter J affil: Department of Radiology, CS Mott Children's Hospital, Section of Pediatric Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA sug: subj: Colon Pathology Crohn Disease Pathology Intestine, Small Pathology Magnetic Resonance Imaging Methods Adolescence Child Female Human Male Reproducibility of Results Sensitivity and Specificity Adolescent: 13-18 years Child: 6-12 years Female Male ab: Background: While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice.Objective: To assess the ability of MRE to identify segments of small bowel and colon affected by pediatric Crohn disease using histopathology as the reference standard.Materials and Methods: Pediatric MRE examinations performed between April 2009 and December 2010 were identified. Subjects were excluded if they did not have Crohn disease, if they had Crohn disease but no correlative histopathology within 2 months of imaging, or if they had undergone prior bowel resection. Pertinent MRE and histopathology reports were reviewed, and normal and abnormal bowel segments were documented.Results: Thirty-two pediatric MRE examinations were identified with correlative histopathology. MRE had an overall sensitivity of 94% for detecting the presence of Crohn disease, in general. At the bowel segmental level, MRE had a sensitivity of 66%, specificity of 90%, positive predictive value of 85% and negative predictive value of 76%. The terminal ileum was abnormal by MRE in 11 of 15 (73%) subjects lacking a diagnostic biopsy of this bowel segment.Conclusion: MRE successfully identifies small bowel and colon segments affected by pediatric Crohn disease. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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