Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI.
Background: Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL).Objective: Evaluate changes in the volume of 116 GM areas in preterm children with d...
| Publicado en: | Pediatric Radiology Vol. 41; no. 12; pp. 1545 - 1552 |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Dec2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104607661&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104607661 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03010449 O03 jtl: Pediatric Radiology issn: 03010449 maglogo: N pubinfo: dt: Dec2011 vid: 41 iid: 12 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104607661 NLM21901522 2011390879 10.1007/s00247-011-2223-z NLM21901522 104607661 ppf: 1545 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Diffuse periventricular leukomalacia in preterm children: assessment of grey matter changes by MRI. aug: au: Tzarouchi LC Xydis V Zikou AK Drougia A Astrakas LG Papastefanaki M Andronikou S Argyropoulou MI Tzarouchi, L C Xydis, V Zikou, A K Drougia, A Astrakas, L G Papastefanaki, M Andronikou, S Argyropoulou, Maria I affil: Department of Radiology, Medical School, University of Ioannina, 45110 Ioannina, Greece sug: subj: Brain Pathology Brain Diseases Pathology Magnetic Resonance Imaging Methods Neurons Pathology Female Human Infant Infant, Newborn Infant, Premature Male Reproducibility of Results Sensitivity and Specificity Infant: 1-23 months Infant, Newborn: birth-1 month Female Male ab: Background: Preterm children may have cognitive deficits and behavioural disorders suggestive of grey matter (GM) injury. The prevalence is higher in preterm children with diffuse periventricular leukomalacia (dPVL).Objective: Evaluate changes in the volume of 116 GM areas in preterm children with dPVL.Methods and Materials: Eleven preterm children with dPVL, gestational age 32.8 ± 2.6 weeks, examined at corrected age 22.0 ± 18.2 months and 33 matched preterm controls with normal brain MRI were studied. Volumes of 116 individual GM areas, and white matter/cerebrospinal fluid (WM/CSF) ratio were calculated on T1-weighted high-resolution images after segmentation.Results: Relative to controls, children with dPVL had decreased GM volume of the hippocampus, amygdala, and frontal lobes and temporal middle gyrus (P < 0.05); increased GM volume of the putamen, thalamus, globus pallidum, superior temporal gyrus and of the parietal and occipital lobes (P < 0.05) and lower WM volume/higher CSF volume (P < 0.05). WM/CSF ratios also differed (P < 0.05).Conclusions: Preterm children with dPVL have increased regional GM volume in some areas probably related with a process of brain plasticity-regeneration and reduced GM volume in areas associated with cognition and memory. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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