Development of a Sampling Patch to Measure Dermal Exposures to Monomeric and Polymeric 1,6-Hexamethylene Diisocyanate: A Pilot Study.
The purpose of this study was to develop and evaluate a patch sampler to monitor dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate (HDI) in the automotive refinishing industry. Different patch materials were used to construct the patches, and patches impregnated with a deriv...
| Published in: | Journal of Occupational & Environmental Hygiene Vol. 8; no. 12; pp. 709 - 718 |
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| Main Authors: | , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Taylor & Francis Ltd
Dec2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104611462&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104611462 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 15459624 V1L jtl: Journal of Occupational & Environmental Hygiene issn: 15459624 maglogo: Y pubinfo: dt: Dec2011 vid: 8 iid: 12 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104611462 67698709 10.1080/15459624.2011.626744 NLM22074266 104611462 ppf: 709 ppct: 9 formats: fmt: @attributes: type: P tig: atl: Development of a Sampling Patch to Measure Dermal Exposures to Monomeric and Polymeric 1,6-Hexamethylene Diisocyanate: A Pilot Study. aug: au: Thomasen, Jennifer M. Fent, Kenneth W. Nylander-French, Leena A. affil: Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, North Carolina sug: subj: Occupational Exposure Prevention and Control Occupational Exposure Evaluation Azepines Adverse Effects Animal Studies North Carolina Guinea Pigs Pilot Studies Paint Paired T-Tests Funding Source ab: The purpose of this study was to develop and evaluate a patch sampler to monitor dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate (HDI) in the automotive refinishing industry. Different patch materials were used to construct the patches, and patches impregnated with a derivatizing solution were compared with those that were not impregnated. We observed that impregnated felt patches measured significantly more HDI monomer (p = 0.04) than non-impregnated patches in a controlled experiment. Both impregnated and non-impregnated patches were compared with the tape-strip method by monitoring three spray painters’ dermal exposure to monomeric and polymeric HDI. Isocyanurate was the predominant species measured by all three sampler types with detectable levels in >86% of samples. Overall, tape-strips of exposed skin measured lower levels of monomeric and polymeric HDI than impregnated patch samplers at the same sampling site on the skin. Unlike tape-strips, impregnated patches are not as prone to evaporative or reactive losses or losses due to rapid penetration into the skin. Further investigations are warranted to evaluate these and other methods to measure dermal exposure to workers under occupational conditions to better understand the relationship between dermal exposure and internal dose. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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