Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity.
Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity. Case-control analyses were performed using 1,533 obese subjects (89...
| Publicado en: | Obesity (19307381) Vol. 20; no. 1; pp. 178 - 186 |
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| Autores principales: | , , , , , , , , , , , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Wiley-Blackwell
Jan2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104619070&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104619070 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 19307381 GSO jtl: Obesity (19307381) issn: 19307381 maglogo: Y pubinfo: dt: Jan2012 vid: 20 iid: 1 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104619070 NLM21760635 2011410654 10.1038/oby.2011.200 NLM21760635 PMC3760128 104619070 ppf: 178 ppct: 8 formats: tig: atl: Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. aug: au: Clark SJ Falchi M Olsson B Jacobson P Cauchi S Balkau B Marre M Lantieri O Andersson JC Jernås M Aitman TJ Richardson S Sjöström L Wong HY Carlsson LM Froguel P Walley AJ Clark, Stephen J Falchi, Mario Olsson, Bob affil: Department of Genomics of Common Diseases, School of Public Health, Imperial College London, Hammersmith Hospital, London, UK sug: subj: Obesity, Morbid Proteins Polymorphism, Genetic Transferases Adolescence Adult Body Mass Index Case Control Studies Child White Persons Female Genes Disease Susceptibility Human Male Obesity, Morbid Epidemiology Odds Ratio Siblings Sweden Biochemical Phenomena Adolescent: 13-18 years Adult: 19-44 years Child: 6-12 years Female Male ab: Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity. Case-control analyses were performed using 1,533 obese subjects (896 adults, BMI >40 kg/m(2) and 637 children, BMI >97th percentile for age and sex) and 1,237 nonobese controls, all French Caucasians. Two SNPs (in high linkage disequilibrium (LD), r(2) = 0.96) were significantly associated with adult obesity, rs33957861 (P value = 0.003, odds ratio (OR) = 0.75, confidence interval (CI) = 0.61-0.92) and rs11599176 (P value: 0.006, OR = 0.74, CI = 0.61-0.90). Expression of SIRT1 mRNA was measured in BMI-discordant siblings from 154 Swedish families. Transcript expression was significantly correlated to BMI in the lean siblings (r(2) = 0.13, P value = 3.36 × 10(-7)) and lower SIRT1 expression was associated with obesity (P value = 1.56 × 10(-35)). There was also an association between four SNPs (rs11599176, rs12413112, rs33957861, and rs35689145) and BMI (P values: 4 × 10(-4), 6 × 10(-4), 4 × 10(-4), and 2 × 10(-3)) with the rare allele associated with a lower BMI. However, no SNP was associated with SIRT1 transcript expression level. In summary, both SNPs and SIRT1 gene expression are associated with severe obesity. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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