Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guided biopsies in peripheral zone tumours.
Objectives: To investigate the usefulness of Apparent Diffusion Coefficients (ADC) in predicting prostatectomy Gleason Grades (pGG) and Scores (GS), compared with ultrasound-guided biopsy Gleason Grades (bGG).Methods: Twenty-four patients with biopsy-proven prostate cancer were included in the study...
| Publicado en: | European Radiology Vol. 22; no. 2; pp. 468 - 476 |
|---|---|
| Autores principales: | , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Feb2012
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104623554&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104623554 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09387994 NPH jtl: European Radiology issn: 09387994 maglogo: N pubinfo: dt: Feb2012 vid: 22 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104623554 NLM21913058 2011421781 10.1007/s00330-011-2269-1 NLM21913058 104623554 ppf: 468 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Prostate MRI: diffusion-weighted imaging at 1.5T correlates better with prostatectomy Gleason Grades than TRUS-guided biopsies in peripheral zone tumours. aug: au: Bittencourt LK Barentsz JO de Miranda LC Gasparetto EL Bittencourt, Leonardo Kayat Barentsz, Jelle O de Miranda, Luiz Carlos Duarte Gasparetto, Emerson Leandro affil: CDPI Clinics-Abdominal and Pelvic Imaging, Rio de Janeiro Federal University, Av. Das Americas, 4666, sl 325, centro medico, 22640102, Rio de Janeiro, RJ, Brazil sug: subj: Magnetic Resonance Imaging Methods Prostate Pathology Prostatic Neoplasms Pathology Prostatic Neoplasms Surgery Ultrasonography Methods Ultrasonic Therapy Methods Aged Pharmacokinetics Biopsy Methods Human Male Middle Age Prospective Studies Prostate Ultrasonography Prostate-Specific Antigen Prostatectomy Methods Prostatic Neoplasms Therapy ROC Curve Reproducibility of Results Aged: 65+ years Middle Aged: 45-64 years Male ab: Objectives: To investigate the usefulness of Apparent Diffusion Coefficients (ADC) in predicting prostatectomy Gleason Grades (pGG) and Scores (GS), compared with ultrasound-guided biopsy Gleason Grades (bGG).Methods: Twenty-four patients with biopsy-proven prostate cancer were included in the study. Diffusion-weighted images were obtained using 1.5-T MR with a pelvic phased-array coil. Median ADC values (b0,500,1000 s/mm²) were measured at the most suspicious areas in the peripheral zone. The relationship between ADC values and pGG or GS was assessed using Pearson's coefficient. The relationship between bGG and pGG or GS was also evaluated. Receiver operating characteristic (ROC) curve analysis was performed to assess the performance of each method on a qualitative level.Results: A significant negative correlation was found between mean ADCs of suspicious lesions and their pGG (r = -0.55; p < 0.01) and GS (r = -0.63; p < 0.01). No significant correlation was found between bGG and pGG (r = 0.042; p > 0.05) or GS (r = 0.048; p > 0.05). ROC analysis revealed a discriminatory performance of AUC = 0.82 for ADC and AUC = 0.46 for bGG in discerning low-grade from intermediate/high-grade lesions.Conclusions: The ADC values of suspicious areas in the peripheral zone perform better than bGG in the correlation with prostate cancer aggressiveness, although with considerable intra-subject heterogeneity.Key Points: • Prostate cancer aggressiveness is probably underestimated and undersampled by routine ultrasound-guided biopsies. • Diffusion-weighted MR images show good linear correlation with prostate cancer aggressiveness. • DWI information may be used to improve risk-assessment in prostate cancer. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|