Resistant Herpes Simplex Virus Infection and HIV: A Potential Diagnostic and Therapeutic Dilemma.
Herpes simplex virus (HSV) is the most frequent cause of genital ulcer disease worldwide. It is also 1 of the leading infections among HIV-infected individuals. Though HSV-2 is the principal etiologic agent of genital HSV infections (GH), HSV-1 has increasingly become a more common cause of GH, part...
| Publicado en: | Laboratory Medicine Vol. 42; no. 8; pp. 452 - 458 |
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| Autores principales: | , , , |
| Formato: | case study pictorial Journal Article |
| Publicado: |
Oxford University Press / USA
Aug2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104626552&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104626552 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00075027 4CY jtl: Laboratory Medicine issn: 00075027 maglogo: N pubinfo: dt: Aug2011 vid: 42 iid: 8 pid: 10398 pub: Oxford University Press / USA artinfo: ui: 104626552 70268061 10.1309/LMMVWC1EX7AW8ZMD 104626552 ppf: 452 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Resistant Herpes Simplex Virus Infection and HIV: A Potential Diagnostic and Therapeutic Dilemma. aug: au: Bush, Larry M. Talledo-Thais, Karla Casal-Fernandez, Alyn Perez, Maria T. affil: Professor of Biomedical Science, Associate Dean of Academic Affairs/JFK Medical Center, Charles E. Schmidt School of Medicine, Florida Atlantic University, Boca Raton, Florida; Associate (voluntary) Professor of Medicine, University of Miami-Miller School of Medicine, Miami sug: subj: Acquired Immunodeficiency Syndrome Physiopathology Herpes Genitalis Drug Therapy Drug Resistance, Microbial Herpes Genitalis Microbiology Middle Age Male Diagnosis, Differential Herpesviruses Classification Comorbidity Antiviral Agents Therapeutic Use Foscarnet Therapeutic Use Diagnosis, Delayed Treatment Failure Herpes Genitalis Diagnosis Mutation Evaluation Herpes Genitalis Familial and Genetic Acquired Immunodeficiency Syndrome Familial and Genetic Genetics, Microbial Middle Aged: 45-64 years Male ab: Herpes simplex virus (HSV) is the most frequent cause of genital ulcer disease worldwide. It is also 1 of the leading infections among HIV-infected individuals. Though HSV-2 is the principal etiologic agent of genital HSV infections (GH), HSV-1 has increasingly become a more common cause of GH, particularly in those with concurrent HIV. The clinical presentation of HSV in HIV-infected patients is often atypical. Individuals with depressed CD4 T-cell lymphocyte counts frequently present with more severe and protracted GH. Extensive, ulcerated, and necrotic lesions may make for a confusing initial clinical diagnosis. Furthermore, treatment with routine anti-herpetic viral agents may result in failure to resolve infection. Motivated by our recent experience involving an AIDS patient with a difficult-to-diagnose genital HSV infection that proved unresponsive to standard treatment, we review the topic of HSV anti-viral medication resistance with particular attention to its association in the HIV/HSV co-infected patient. pubtype: Academic Journal doctype: case study pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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