Teratoma with Malignant Transformation: A Case Report with Pathological, Cytogenetic, and Immunohistochemistry Analysis.
Background. Teratoma withmalignant transformation (TMT) is rare and most commonly encountered in adult patient with germ cell tumor (GCT). Method. We report a rare case of testicular teratoma with metastatic TMT/embryonal rhabdomyosarcoma (ERMS). A 44-year-old man underwent right orchiectomy which r...
| Publicado en: | Sarcoma pp. 1 - 6 |
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| Autores principales: | , |
| Formato: | case study diagnostic images pictorial Journal Article |
| Publicado: |
Wiley-Blackwell
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104626578&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104626578 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1357714X 57R jtl: Sarcoma issn: 1357714X maglogo: Y pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104626578 104626578 2011420243 NLM21776193 PMC3138084 104626578 ppf: 1 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Teratoma with Malignant Transformation: A Case Report with Pathological, Cytogenetic, and Immunohistochemistry Analysis. aug: au: Jue Wang Jaffar Kazmi, Syed A. affil: Department of Internal Medicine, Section of Oncology-Hematology, University of Nebraska Medical Center, Omaha, NE 68198-7680, USA sug: subj: Teratoma Pathology Cell Transformation, Neoplastic Rhabdomyosarcoma Pathology Germinoma Pathology Teratoma Therapy Rhabdomyosarcoma Therapy Germinoma Therapy Cytogenetic Analysis Immunohistochemistry Adult Male Neoplasm Metastasis Biological Markers Combined Modality Therapy Lung Neoplasms Therapy Testicular Neoplasms Therapy Liver Neoplasms Therapy In Situ Hybridization, Fluorescence Adult: 19-44 years Male ab: Background. Teratoma withmalignant transformation (TMT) is rare and most commonly encountered in adult patient with germ cell tumor (GCT). Method. We report a rare case of testicular teratoma with metastatic TMT/embryonal rhabdomyosarcoma (ERMS). A 44-year-old man underwent right orchiectomy which revealed a malignant teratoma, he subsequently had right pneumonectomy with two pulmonarymasses containing a high-grade embryonal rhabdomyosarcoma. The patient developed liver metastasis three months after initial diagnosis. He was treated with a chemotherapy regimen with vincristine, dactinomycin, and cyclophosphamide (VAC) alternating with vincristine and irinotecan (VI) with complete resolution of his liver lesion. The tumors were examined with a battery of cytogenetic, immunohistochemical, and molecular assays. Results. The malignant cells were immunohistochemically positive for desmin, myogenin, and Myo D1. Molecular cytogenetics of embryonal rhabdomyosarcoma tissue revealed the presence of i(12p). The tumor expressed high level of TOPO2A, TOPO1, MRP1, MGMT, BCRP, ERCC1, RRM1, and TS. Conclusion. The activity of topoisomerase inhibitors and the potential usefulness of topoisomerase expression as biomarkers should be further tested in aprospective study. pubtype: Academic Journal doctype: case study diagnostic images pictorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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