Connexin 43 Is a Potential Prognostic Biomarker for Ewing Sarcoma/Primitive Neuroectodermal Tumor.
Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are prognostic markers in carcinomas. To investigate the role of Cx in Ewing sarcoma (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactiv...
| Published in: | Sarcoma pp. 1 - 8 |
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| Main Authors: | , , , , , , |
| Format: | pictorial research tables/charts Journal Article |
| Published: |
Wiley-Blackwell
2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104626591&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104626591 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 1357714X 57R jtl: Sarcoma issn: 1357714X maglogo: Y pubinfo: dt: 2011 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104626591 104626591 2011420253 NLM21647307 PMC3103998 104626591 ppf: 1 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Connexin 43 Is a Potential Prognostic Biomarker for Ewing Sarcoma/Primitive Neuroectodermal Tumor. aug: au: Bui, Marilyn M. Gang Han Acs, Geza Reed, Damon Gonzalez, Ricardo J. Pasha, T. L. Zhang, Paul J. affil: Department of Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA; Program of Experimental Therapeutics, Moffitt Cancer Center, Tampa, FL 33612, USA sug: subj: Sarcoma, Ewing's Prognosis Neuroectodermal Tumors, Primitive Prognosis Membrane Proteins Biological Markers Sarcoma, Ewing's Mortality Neuroectodermal Tumors, Primitive Mortality Human Retrospective Design Tissue Array Analysis Immunohistochemistry Descriptive Statistics Mann-Whitney U Test Kaplan-Meier Estimator Log-Rank Test Data Analysis Software Confidence Intervals Cox Proportional Hazards Model Neoplasm Metastasis Male Female Adult Adolescence Aged Middle Age Child Sarcoma, Ewing's Pathology Neuroectodermal Tumors, Primitive Pathology Funding Source Adult: 19-44 years Adolescent: 13-18 years Aged: 65+ years Middle Aged: 45-64 years Child: 6-12 years Male Female ab: Connexins (Cxs) are building unit proteins of gap junctions (GJs) that are prognostic markers in carcinomas. To investigate the role of Cx in Ewing sarcoma (EWS)/primitive neuroectodermal tumor (PNET), we examined the expression of Cx43 and Cx26 in 36 EWS/PNETs and found (1) cytoplasmic Cx43 reactivity in 28/36 (78%) cases. (2) Cx43 score was significantly correlated with overall survival (P = .025). The average scores for patients alive and dead at 3 years are 46.08 and 96.98 (P = .004) at 5 years are 46.06 and 96.42 (P = .002). (3) Metastasis had a significant effect on the overall survival (P = .003). (4) Cytoplasmic Cx26 reactivity was detected in 2 of 36 (6%) patients who died with metastasis. Our results suggest a possible oncogenic and prognostic role for Cx43 and Cx26 in EWS/PNET. The lack of membranous immunoreactivity suggests that the effect of Cx in EWS/PNET is via a GJ function-independent mechanism. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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