IMRT for image-guided single vocal cord irradiation.
Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modul...
| Published in: | International Journal of Radiation Oncology, Biology, Physics Vol. 82; no. 2; pp. 989 - 998 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , |
| Format: | research Journal Article |
| Published: |
Pergamon Press - An Imprint of Elsevier Science
Feb2012
|
| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104629109&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104629109 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Feb2012 vid: 82 iid: 2 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 104629109 NLM21300449 2011429736 10.1016/j.ijrobp.2010.12.022 NLM21300449 104629109 ppf: 989 ppct: 9 formats: tig: atl: IMRT for image-guided single vocal cord irradiation. aug: au: Osman SO Astreinidou E de Boer HC Keskin-Cambay F Breedveld S Voet P Al-Mamgani A Heijmen BJ Levendag PC Osman, Sarah O S Astreinidou, Eleftheria de Boer, Hans C J Keskin-Cambay, Fatma Breedveld, Sebastiaan Voet, Peter Al-Mamgani, Abrahim Heijmen, Ben J M Levendag, Peter C affil: Department of Radiation Oncology, Erasmus Medical Center-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands sug: subj: Laryngeal Neoplasms Radiotherapy Radiotherapy, Computer-Assisted Methods Radiotherapy Methods Radiotherapy, Conformal Methods Vocal Cords Radiography Algorithms Arytenoid Cartilage Radiography Radiation Dosage Human Laryngeal Muscles Radiography Laryngeal Neoplasms Radiography Systems Analysis Body Regions Radiography Pharyngeal Muscles Radiography Radiation Injuries Prevention and Control Body Weights and Measures ab: Purpose: We have been developing an image-guided single vocal cord irradiation technique to treat patients with stage T1a glottic carcinoma. In the present study, we compared the dose coverage to the affected vocal cord and the dose delivered to the organs at risk using conventional, intensity-modulated radiotherapy (IMRT) coplanar, and IMRT non-coplanar techniques. Methods and Materials: For 10 patients, conventional treatment plans using two laterally opposed wedged 6-MV photon beams were calculated in XiO (Elekta-CMS treatment planning system). An in-house IMRT/beam angle optimization algorithm was used to obtain the coplanar and non-coplanar optimized beam angles. Using these angles, the IMRT plans were generated in Monaco (IMRT treatment planning system, Elekta-CMS) with the implemented Monte Carlo dose calculation algorithm. The organs at risk included the contralateral vocal cord, arytenoids, swallowing muscles, carotid arteries, and spinal cord. The prescription dose was 66 Gy in 33 fractions. Results: For the conventional plans and coplanar and non-coplanar IMRT plans, the population-averaged mean dose ± standard deviation to the planning target volume was 67 ± 1 Gy. The contralateral vocal cord dose was reduced from 66 ± 1 Gy in the conventional plans to 39 ± 8 Gy and 36 ± 6 Gy in the coplanar and non-coplanar IMRT plans, respectively. IMRT consistently reduced the doses to the other organs at risk. Conclusions: Single vocal cord irradiation with IMRT resulted in good target coverage and provided significant sparing of the critical structures. This has the potential to improve the quality-of-life outcomes after RT and maintain the same local control rates. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|