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Partial motor restoration upon administration of sildenafil: a case study.

Objective: Extensive research in the past decade has confirmed that the adult brain maintains some plasticity, including neural cell birth, migration and integration. Pre-clinical data strongly suggest that phosphodiesterase type 5 (PDE5) inhibitors promote cerebral neovascularization and neurogenes...

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Published in:Developmental Neurorehabilitation Vol. 15; no. 1; pp. 39 - 44
Main Author: Cocchiarella, Antonio
Format: case study pictorial research tables/charts Journal Article
Published: Taylor & Francis Ltd Feb2012
Online Access:View this record in EBSCOhost
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      dt: Feb2012
      vid: 15
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      pub: Taylor & Francis Ltd
      place: Philadelphia, Pennsylvania
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      tig:
        atl: Partial motor restoration upon administration of sildenafil: a case study.
      aug:
        au: Cocchiarella, Antonio
      sug:
        subj:
          Brain Blood Supply
          Cerebrovascular Circulation Drug Effects
          Persons with Disabilities
          Motor Skills Drug Effects
          Muscle Strength Drug Effects
          Quadriplegia Rehabilitation
          Neural Conduction Drug Effects
          Cell Differentiation Drug Effects
          Cell Differentiation Physiology
          Neuronal Plasticity
          Phosphodiesterase Inhibitors Administration and Dosage
          Phosphodiesterase Inhibitors Pharmacodynamics
          Phosphodiesterase Inhibitors Therapeutic Use
          Sildenafil Therapeutic Use
          Sildenafil Administration and Dosage
          Sildenafil Pharmacodynamics
          Neovascularization, Physiologic
          Human
          Adult
          Male
          Experimental Studies
          Electromyography
          Sildenafil Adverse Effects
          Adult: 19-44 years
          Male
      ab: Objective: Extensive research in the past decade has confirmed that the adult brain maintains some plasticity, including neural cell birth, migration and integration. Pre-clinical data strongly suggest that phosphodiesterase type 5 (PDE5) inhibitors promote cerebral neovascularization and neurogenesis. Animal studies of cerebral stroke suggest potential regenerative benefits following treatment with sildenafil citrate, a PDE5 inhibitor. This study reports a case in which compassionate use of sildenafil was investigated as a treatment to improve physical functioning, more than 4 decades after development of spastic quadriplegia during the 1st-2nd year of life. Methods: Sildenafil 100 mg was administered every 24 hours for 7 months. Results: Sildenafil treatment was associated with clinical (functional) improvement. Conclusions: The activity of sildenafil on cerebral neovascularization and neurogenesis may be the mechanism for the observed functional benefits.
      pubtype: Academic Journal
      doctype:
        case study
        pictorial
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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