Movement disorders: role of imaging in diagnosis.
Magnetic resonance imaging (MRI and single-photon emission computed tomography (SPECT) have a considerable role in the diagnosis of the single patient with movement disorders. Conventional MRI demonstrates symptomatic causes of parkinsonism but does not show any specific finding in Parkinson's disea...
| Publicado en: | Journal of Magnetic Resonance Imaging Vol. 35; no. 2; pp. 239 - 257 |
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| Autores principales: | , , , , , |
| Formato: | review Journal Article |
| Publicado: |
Wiley-Blackwell
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104633248&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104633248 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10531807 O63 jtl: Journal of Magnetic Resonance Imaging issn: 10531807 maglogo: Y pubinfo: dt: Feb2012 vid: 35 iid: 2 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104633248 NLM22271273 2011436236 10.1002/jmri.22825 NLM22271273 104633248 ppf: 239 ppct: 18 formats: tig: atl: Movement disorders: role of imaging in diagnosis. aug: au: Mascalchi M Vella A Ceravolo R Mascalchi, Mario Vella, Alessandra Ceravolo, Roberto affil: Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy sug: subj: Magnetic Resonance Imaging Methods Movement Disorders Diagnosis Movement Disorders Radiography Tomography, Emission-Computed, Single-Photon Methods Algorithms Image Interpretation, Computer Assisted Movement Disorders Etiology Tomography, Emission-Computed Tomography, X-Ray Computed ab: Magnetic resonance imaging (MRI and single-photon emission computed tomography (SPECT) have a considerable role in the diagnosis of the single patient with movement disorders. Conventional MRI demonstrates symptomatic causes of parkinsonism but does not show any specific finding in Parkinson's disease (PD). However, SPECT using tracers of the dopamine transporter (DAT) demonstrates an asymmetric decrease of the uptake in the putamen and caudate from the earliest clinical stages. In other degenerative forms of parkinsonism, including progressive supranuclear palsy (PSP), multisystem atrophy (MSA), and corticobasal degeneration (CBD), MRI reveals characteristic patterns of regional atrophy combined with signal changes or microstructural changes in the basal ganglia, pons, middle and superior cerebellar peduncles, and cerebral subcortical white matter. SPECT demonstrates a decreased uptake of tracers of the dopamine D2 receptors in the striata of patients with PSP and MSA, which is not observed in early PD. MRI also significantly contributes to the diagnosis of some inherited hyperkinetic conditions including neurodegeneration with brain iron accumulation and fragile-X tremor/ataxia syndrome by revealing characteristic symmetric signal changes in the basal ganglia and middle cerebellar peduncles, respectively. A combination of the clinical features with MRI and SPECT is recommended for optimization of the diagnostic algorithm in movement disorders. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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