Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ.
Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal 'social' brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirtee...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 42; no. 2; pp. 313 - 319 |
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| Autores principales: | , , , , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
Springer Nature
Feb2012
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104634059&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104634059 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Feb2012 vid: 42 iid: 2 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104634059 70530892 10.1007/s10803-011-1240-y NLM21487836 104634059 ppf: 313 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ. aug: au: Pagani, Marco Manouilenko, Irina Stone-Elander, Sharon Odh, Richard Salmaso, Dario Hatherly, Robert Brolin, Fredrik Jacobsson, Hans Larsson, Stig Bejerot, Susanne affil: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm Sweden sug: subj: Autism Spectrum Disorder Radiography Tomography, Emission-Computed Cerebrovascular Circulation Human Male Female Interview Guides Intelligence Tests Descriptive Statistics Interviews Young Adult Adult Chi Square Test Fisher's Exact Test T-Tests Brain Pathology Funding Source Adult: 19-44 years Male Female ab: Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal 'social' brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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