A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins.
Purpose: Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorp...
| Published in: | European Journal of Nutrition Vol. 51; no. 1; pp. 47 - 56 |
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| Main Authors: | , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Springer Nature
Feb2012
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104634114&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104634114 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14366207 CR0 jtl: European Journal of Nutrition issn: 14366207 maglogo: N pubinfo: dt: Feb2012 vid: 51 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104634114 70531092 10.1007/s00394-011-0189-0 NLM21445620 104634114 ppf: 47 ppct: 9 formats: fmt: @attributes: type: P tig: atl: A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins. aug: au: Miller, Rosalind Jackson, Kim Dadd, Tony Nicol, Beate Dick, Joanne Mayes, Andrew Brown, A. Minihane, Anne affil: Department of Food and Nutritional Sciences, University of Reading, Whiteknights Reading RG6 6AP UK sug: subj: Green Tea Plant Extracts Pharmacokinetics Genotype Polyphenols Pharmacokinetics United Kingdom Human Pilot Studies Prospective Studies Body Mass Index Evaluation Middle Age Descriptive Statistics Chromatography, High Pressure Liquid Polyphenols Blood Biological Availability Data Analysis Software Male Female Comparative Studies Middle Aged: 45-64 years Male Female ab: Purpose: Green tea is thought to possess many beneficial effects on human health. However, the extent of green tea polyphenol biotransformation may affect its proposed therapeutic effects. Catechol-O-methyltransferase (COMT), the enzyme responsible for polyphenolic methylation, has a common polymorphism in the genetic code at position 158 reported to result in a 40% reduction in enzyme activity in in vitro studies. The current preliminary study was designed to investigate the impact of COMT genotype on green tea catechin absorption and metabolism in humans. Methods: Twenty participants (10 of each homozygous COMT genotype) were recruited, and plasma concentration profiles were produced for epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epicatechin (EC) and 4′-O-methyl EGCG after 1.1 g of Sunphenon decaffeinated green tea extract (836 mg green tea catechins), with a meal given after 60 min. Results: For the entire group, EGCG, EGC, EC, ECG and 4′-O-methyl EGCG reached maximum concentrations of 1.09, 0.41, 0.33, 0.16 and 0.08 μM at 81.5, 98.5, 99.0, 85.5 and 96.5 min, respectively. Bimodal curves were observed for the non-gallated green tea catechins EGC and EC as opposed to single-peaked curves for the gallated green tea catechins EGCG and ECG. No significant parametric differences between COMT genotype groups were found. Conclusions: In conclusion, the COMT Val(158/108)Met does not appear to have a dramatic influence on EGCG absorption and elimination. However, further pharmacokinetic research is needed to substantiate these findings. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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