| Sumario: | Cryptococcal meningitis usually appears in immunosuppressed patients [organ transplant receivers, in patients with malignancies and in patients with acquired immune deficiency syndrome (AIDS)]. Cryptococcal meningitis in the immunocompetent hosts has been reported rarely in the literature. This paper represents a case of cryptococcal meningitis in a previously healthy 25-year-old man. The case had the classical clinical and examnination findings of menengitis, therefore, the microbiological analysis of the cerebrospinal fluid (CSF) was rather useful in the differential diagnosis. We detected capsulated yeast cells in the analysis of CSF with methylene blue. The CSF Cryptococcus antigen (CRAG) test result was negative, but we were able to grow and detect Cryptococcus neoformans on culture. The patient received classical amphotericin-B therapy at the beginning, but due to a drug reaction we changed it with the lipposomal amphotericin-B, and after 21 days of therapy the patient was discharged without any sequele.
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