| Sumario: | Wells syndrome, also known as eosinophilic syndrome, is an uncommon, inflammatory dermatosis with unknown etiology. Classical lesion is pruritic, erythematous, edematous and seen as infiltrative acute cellulitis like plaques. It is primarily disease of adults, and about 20 cases have been reported in children. Characteristic histopathological features are edema, flame figures, and the marked infiltrate of eosinophils in the dermis. Papular, bullous and nodular forms are uncommon clinical lesions. Lesions regress spontaneously over several weeks to months, however they may recur frequently. Antimicrobial therapy is not effective for resolving lesions. Peripheral eosinophilia has been detected in half of the reported cases when disease is in active period. We hereby report two cases of Wells syndrome, first with acute cellulitis-like and the second with papular form, and review of literature.
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