Population- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families.
Two methylenetetrahydrofolate reductase gene ( MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case-control comparisons revealed a significantly higher frequency of the low...
| Publicado en: | Journal of Autism & Developmental Disorders Vol. 41; no. 7; pp. 938 - 945 |
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| Autores principales: | , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Springer Nature
Jul2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104644279&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104644279 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01623257 AUT jtl: Journal of Autism & Developmental Disorders issn: 01623257 maglogo: N pubinfo: dt: Jul2011 vid: 41 iid: 7 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104644279 61235823 10.1007/s10803-010-1120-x NLM21069446 104644279 ppf: 938 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Population- and Family-Based Studies Associate the MTHFR Gene with Idiopathic Autism in Simplex Families. aug: au: Liu, Xudong Solehdin, Fatima Cohen, Ira Gonzalez, Maripaz Jenkins, Edmund Lewis, M. Holden, Jeanette sug: subj: Oxidoreductases Polymorphism, Genetic Autism Spectrum Disorder Family Human Methylation Risk Factors Intelligence Tests Case Control Studies Male Female DNA Analysis Genotype Chi Square Test Data Analysis Software Funding Source Random Sample Alleles Male Female ab: Two methylenetetrahydrofolate reductase gene ( MTHFR) functional polymorphisms were studied in 205 North American simplex (SPX) and 307 multiplex (MPX) families having one or more children with an autism spectrum disorder. Case-control comparisons revealed a significantly higher frequency of the low-activity 677T allele, higher prevalence of the 677TT genotype and higher frequencies of the 677T-1298A haplotype and double homozygous 677TT/1298AA genotype in affected individuals relative to controls. Family-based association testing demonstrated significant preferential transmission of the 677T and 1298A alleles and the 677T-1298A haplotype to affected offspring. The results were not replicated in MPX families. The results associate the MTHFR gene with autism in SPX families only, suggesting that reduced MTHFR activity is a risk factor for autism in these families. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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