Delayed effect of blood pressure fluctuations on heart rate in patients with end-stage kidney disease.
The time delay of the baroreflex may be affected by decreased autonomic activity in uremia. To assess the magnitude and the time delay of heart rate response in patients with end-stage renal disease, continuous beat-to-beat intervals (IBI) and systolic blood pressure (SBP) recordings were monitored...
| Publicado en: | Medical & Biological Engineering & Computing Vol. 49; no. 9; pp. 1045 - 1056 |
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| Autores principales: | , , , |
| Formato: | research Journal Article |
| Publicado: |
Springer Nature
Sep2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104672791&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104672791 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01400118 PO0 jtl: Medical & Biological Engineering & Computing issn: 01400118 maglogo: N pubinfo: dt: Sep2011 vid: 49 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104672791 NLM21755317 2011248240 10.1007/s11517-011-0806-3 NLM21755317 104672791 ppf: 1045 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Delayed effect of blood pressure fluctuations on heart rate in patients with end-stage kidney disease. aug: au: Sapoznikov D Rubinger D Sapoznikov, Dan Rubinger, Dvora affil: Department of Medicine, Nephrology and Hypertension Services, Hadassah University Medical Center, Ein Kerem 91120, P. O. Box 12000, Jerusalem, Israel sug: subj: Blood Pressure Physiology Heart Rate Physiology Kidney Failure, Chronic Physiopathology Adult Aged Baroreflex Physiology Case Control Studies Female Kidney Failure, Chronic Therapy Kidney Transplantation Male Middle Age Postoperative Period Hemodialysis Signal Processing, Computer Assisted Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: The time delay of the baroreflex may be affected by decreased autonomic activity in uremia. To assess the magnitude and the time delay of heart rate response in patients with end-stage renal disease, continuous beat-to-beat intervals (IBI) and systolic blood pressure (SBP) recordings were monitored in hemodialysis (HD) patients (n = 72), in patients after renal transplantation (TX) (n = 41) and in age-matched controls (C) (n = 34). A 2-term prediction model was computed, in which each IBI change was represented as a function of SBP difference values of two immediately preceding beats. Baroreflex slope and the frequency domain variables low frequency (LF) α index, phase shift, and lag time were also calculated. b₁ coefficient, representing the dependence of IBI difference with the first previous SBP difference was lower in HD than in Cs, but increased after TX. b₁ correlated with age, baroreflex slope, and LF α, and b₂ (the 2nd term), with both the phase shift between SBP and IBI and lag time. The latter was lower in Cs than in HD or transplanted patients. These findings show that the time delay of the heart rate response to SBP variations is increased in renal insufficiency. The prolonged delay may contribute to the circulatory instability in uremic patients. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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