Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients.
Purpose: The pathogenic role of angiotensin-converting enzyme (ACE) inhibition in hypertensive patients regarding endothelial progenitor-cell (EPC) function is still poorly understood. The aim of the study was to evaluate EPC number, function, and relationship to carotid intima media thickness (IMT)...
| Publicado en: | European Journal of Clinical Pharmacology Vol. 67; no. 9; pp. 877 - 884 |
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| Autores principales: | , , , , , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Springer Nature
Sep2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104676883&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104676883 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00316970 NP9 jtl: European Journal of Clinical Pharmacology issn: 00316970 maglogo: N pubinfo: dt: Sep2011 vid: 67 iid: 9 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104676883 64129392 10.1007/s00228-011-1029-0 NLM21445638 104676883 ppf: 877 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. aug: au: Cacciatore, Francesco Bruzzese, Giuseppe Vitale, Dino Liguori, Antonio Nigris, Filomena Fiorito, Carmela Infante, Teresa Donatelli, Francesco Minucci, Pellegrino Ignarro, Louis Napoli, Claudio affil: Cardiovascular Rehabilitation, Salvatore Maugeri Foundation, IRCCS, Institute of Telese, 82037 Benevento Italy sug: subj: Hypertension Drug Therapy Angiotensin-Converting Enzyme Inhibitors Therapeutic Use Enalapril Therapeutic Use Enalapril Pharmacodynamics Angiotensin-Converting Enzyme Inhibitors Pharmacodynamics Clinical Trials Stem Cells Drug Effects Oxidative Stress Drug Effects Human Random Assignment Angiotensin-Converting Enzyme Inhibitors Administration and Dosage Enalapril Administration and Dosage Carotid Arteries Ultrasonography Carotid Arteries Drug Effects Nitrates Blood Linear Regression Epithelial Cells Drug Effects Blood Pressure Determination Nitrites Blood Descriptive Statistics Analysis of Variance Repeated Measures Adult Middle Age Male Female Multivariate Analysis Funding Source Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Purpose: The pathogenic role of angiotensin-converting enzyme (ACE) inhibition in hypertensive patients regarding endothelial progenitor-cell (EPC) function is still poorly understood. The aim of the study was to evaluate EPC number, function, and relationship to carotid intima media thickness (IMT) progression. Methods: We studied 36 newly diagnosed mildly hypertensive patients free of cardiovascular disease and related risk factors without prior or concurrent therapy with ACE inhibitors. Patients were randomized to receive enalapril 20 mg/day ( n = 18) or zofenopril 30 mg/day ( n = 18). EPC number and migrating capacity, plasma nitrite and nitrate (NOx), and isoprostane concentrations were evaluated. Carotid IMT was determined by ultrasonography at baseline and after 1 and 5 years of follow-up. Results: EPC number increased during the follow-up, with no statistical differences between treatment groups. There was an inverse correlation between circulating EPCs and IMT increase over time. Plasma NOx decreased during the study without evident differences between treatment groups. Isoprostanes decreased more markedly in zofenopril-treated patients. Multiple linear regression model demonstrated that carotid IMT was significantly inversely correlated with EPC but not with migratory cells after adjusting for confounders. Conclusions: The study demonstrated that EPC levels increased during the follow-up in both groups of newly diagnosed hypertensive patients treated with ACE inhibitors. These drugs prevented progression of vascular damage, with an inverse correlation between circulating EPC levels and IMT values. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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