Improved Activation Time Assignment of Unipolar Electrograms from Ischemic Canine Epicardium.
Aims: The present study attempts to develop an objective, statistically based set of criteria for activation time determination from unipolar electrograms (U-EGMs) using a standard of activation related to biophysical theory. Methods: A high-resolution assembly of U-EGMs obtained from the epicardial...
| Publicado en: | Pacing & Clinical Electrophysiology Vol. 34; no. 9; pp. 1105 - 1116 |
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| Autores principales: | , , , , |
| Formato: | equations & formulas pictorial research tables/charts tracings Journal Article |
| Publicado: |
Wiley-Blackwell
Sep2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104683454&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104683454 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 01478389 4F8 jtl: Pacing & Clinical Electrophysiology issn: 01478389 maglogo: Y pubinfo: dt: Sep2011 vid: 34 iid: 9 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104683454 65217610 10.1111/j.1540-8159.2011.03116.x NLM21535037 104683454 ppf: 1105 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Improved Activation Time Assignment of Unipolar Electrograms from Ischemic Canine Epicardium. aug: au: Caref, Edward B. Ndrepepa, Gjin Turitto, Gioia Restivo, Mark El-Sherif, Nabil affil: State University of New York Health Science Center at Brooklyn and NY Harbor VA Healthcare System, Brooklyn, New York sug: subj: Biophysiological Methods Electrophysiology Standards Time Factors Myocardial Ischemia Physiopathology Pericardium Physiopathology Body Surface Potential Mapping Methods Animal Studies Dogs Algorithms Electric Stimulation Data Analysis Software Descriptive Statistics Linear Regression Funding Source ab: Aims: The present study attempts to develop an objective, statistically based set of criteria for activation time determination from unipolar electrograms (U-EGMs) using a standard of activation related to biophysical theory. Methods: A high-resolution assembly of U-EGMs obtained from the epicardial surface of the canine postinfarction heart were analyzed in order to achieve the best prediction of local versus distant activation. An activation time standard (ATS) consisted of three properties: (1) propagation of activation, evidenced by a linear temporal shift of waveforms from closely spaced U-EGMs with little or no decay in amplitude; (2) cycle length-dependent changes of those propagating waveforms; and (3) evidence of electrotonic deflections, seen as nonpropagating potentials having decaying amplitude with distance. Results: A number of U-EGM features were calculated and subjected to analysis by comparing their occurrence with the ATS. A discriminant function analysis incorporating multiple features (Voltage, −dV/dt and Ratio) of major U-EGM deflections improved prediction of activation time of complex fractionated EMGs from ischemic canine epicardium to 90%. Conclusion: A unique discriminant function based on sound biophysical principles markedly improved prediction of activation time of complex U-EGMs from ischemic canine epicardium. A computerized version of the algorithm could be developed to provide more accurate activation maps for both basic and clinical use. (PACE 2011; 34:1105-1115) pubtype: Academic Journal doctype: equations & formulas pictorial research tables/charts tracings Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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