Efficacy and safety of a pharmacist-managed inpatient anticoagulation service for warfarin initiation and titration.
Summary What is known and Objective: Anticoagulation consultations provided by a pharmacist-staffed inpatient service, similar to the experience reported in outpatient anticoagulation clinics, can potentially improve anticoagulation control and outcomes. At Tan Tock Seng Hospital, a 1200-bed acute c...
| Publicado en: | Journal of Clinical Pharmacy & Therapeutics Vol. 36; no. 5; pp. 585 - 592 |
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| Autores principales: | , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Wiley-Blackwell
Oct2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104685565&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104685565 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02694727 EV4 jtl: Journal of Clinical Pharmacy & Therapeutics issn: 02694727 maglogo: Y pubinfo: dt: Oct2011 vid: 36 iid: 5 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 104685565 65430243 10.1111/j.1365-2710.2010.01216.x NLM21070296 104685565 ppf: 585 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Efficacy and safety of a pharmacist-managed inpatient anticoagulation service for warfarin initiation and titration. aug: au: Wong, Y. M. Quek, Y.-N. Tay, J. C. Chadachan, V. Lee, H. K. affil: Pharmacy Department sug: subj: Warfarin Administration and Dosage Pharmacy Service Methods Pharmacy Service Evaluation Treatment Outcomes Singapore Academic Medical Centers Inpatients Prospective Studies Human International Normalized Ratio Program Implementation Fisher's Exact Test Mann-Whitney U Test Linear Regression Sensitivity and Specificity Data Analysis Software Male Female Aged Middle Age Aged, 80 and Over Aged: 65+ years Middle Aged: 45-64 years Aged, 80 & over Male Female ab: Summary What is known and Objective: Anticoagulation consultations provided by a pharmacist-staffed inpatient service, similar to the experience reported in outpatient anticoagulation clinics, can potentially improve anticoagulation control and outcomes. At Tan Tock Seng Hospital, a 1200-bed acute care teaching hospital in Singapore, pharmacist-managed anticoagulation clinics have been in place since 1997. Pharmacist-managed services were extended to inpatient consultations in anticoagulation management from April 2006. Our objective was to assess the effect of implementing a pharmacist-managed inpatient anticoagulation service. Methods: This was a single-centre cohort study. Baseline data from 1 January 2006 to 31 March 2006 were collected and compared with post-implementation data from 1 April 2006 to 31 March 2007. Patients newly started on warfarin for deep vein thrombosis, pulmonary embolism or atrial fibrillation in general medicine and surgery departments were included. The three endpoints were as follows: (i) percentage of international normalized ratios (INRs) achieving therapeutic range within 5 days, (ii) INRs more than 4 during titration and (iii) subtherapeutic INRs on discharge. Results and Discussion: A total of 26 patients in the control period were compared with 144 patients who had received dosing consultations by a pharmacist during the initiation of warfarin. The provision of pharmacist consult resulted in 88% compared to 38% ( P < 0·001) of INR values achieving therapeutic range within 5 days. There was a reduction in INR values of more than 4 during titration from 27% to 2% ( P < 0·001), and subtherapeutic INR values on discharge without low molecular weight heparin from 15% to 0% ( P < 0·001). The mean time to therapeutic INR was reduced from 6·5 to 3·9 days ( P < 0·001) and mean length of stay after initiation of warfarin from 11 to 7·7 days ( P = 0·004). What is new and Conclusion: Inpatient anticoagulation care and outcomes were significantly improved by a pharmacist-managed anticoagulation service. The time to therapeutic INR was achieved appropriately and efficiently without compromising patient's safety. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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