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Exacerbation history is associated with medication and appointment adherence in MS.

Disease-modifying treatments are designed to prevent exacerbations in multiple sclerosis (MS). To date, few studies have examined the relationship between disease activity and treatment adherence in MS. The primary aim of this study was to examine the association between disease activity (e.g., annu...

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Published in:Journal of Behavioral Medicine Vol. 34; no. 5; pp. 330 - 339
Main Authors: Hancock, Laura, Bruce, Jared, Lynch, Sharon
Format: research tables/charts Journal Article
Published: Springer Nature Oct2011
Online Access:View this record in EBSCOhost
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      dt: Oct2011
      vid: 34
      iid: 5
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      pub: Springer Nature
      place: New York, New York
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        10.1007/s10865-011-9316-x
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        atl: Exacerbation history is associated with medication and appointment adherence in MS.
      aug:
        au:
          Hancock, Laura
          Bruce, Jared
          Lynch, Sharon
        affil: Department of Psychology, University of Missouri-Kansas City, 4825 Troost Ave., Suite 124 Kansas City 64110 USA
      sug:
        subj:
          Multiple Sclerosis Psychosocial Factors
          Disease Exacerbation Psychosocial Factors
          Medication Compliance Evaluation
          Patient Compliance Evaluation
          Appointments and Schedules
          Recurrence
          Multiple Sclerosis Drug Therapy
          Retrospective Design
          Kansas
          Record Review
          Immunologic Factors Therapeutic Use
          Questionnaires
          Scales
          Data Analysis Software
          Spearman's Rank Correlation Coefficient
          Nonparametric Statistics
          Correlational Studies
          Mann-Whitney U Test
          Human
          Male
          Female
          Middle Age
          Adult
          Chi Square Test
          Self Report
          Multiple Sclerosis Symptoms
          Funding Source
          Middle Aged: 45-64 years
          Adult: 19-44 years
          Male
          Female
      ab: Disease-modifying treatments are designed to prevent exacerbations in multiple sclerosis (MS). To date, few studies have examined the relationship between disease activity and treatment adherence in MS. The primary aim of this study was to examine the association between disease activity (e.g., annualized relapse rates), medication adherence, and appointment adherence in relapsing-remitting MS. Retrospective exacerbation and appointment data were collected and used to predict prospective medication adherence. Results indicated that patients with higher annualized relapse rates missed fewer doses of medication and were less likely to miss appointments. Conversely, patients with relatively stable disease were more likely to demonstrate poor medication adherence and poor appointment adherence. Patients who missed more appointments also missed more doses of their disease modifying medication. Future studies may wish to examine clinical methods designed to improve immunotherapy adherence among patients who are in relatively symptom-free stages of relapsing-remitting MS.
      pubtype: Academic Journal
      doctype:
        research
        tables/charts
        Journal Article
      ougenre: Article
    language: English
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