Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss.
Conclusion: Low plasma melatonin is significant in the development of high frequency hearing loss (HL) among the elderly. Objective: To determine the correlation between hearing threshold and the plasma melatonin and ascorbic acid (vitamin C). Methods: This was a cross-sectional study involving 126...
| Publicado en: | Acta Oto-Laryngologica Vol. 131; no. 11; pp. 1160 - 1165 |
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| Autores principales: | , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104693364&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104693364 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00016489 B6D jtl: Acta Oto-Laryngologica issn: 00016489 maglogo: Y pubinfo: dt: Nov2011 vid: 131 iid: 11 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104693364 66310972 10.3109/00016489.2010.549840 NLM21970786 104693364 ppf: 1160 ppct: 5 formats: fmt: @attributes: type: P tig: atl: Correlation between plasma levels of radical scavengers and hearing threshold among elderly subjects with age-related hearing loss. aug: au: Lasisi, Akeem Olawale Fehintola, Fatai A. sug: subj: Aging Hearing Disorders Immunology Melatonin Blood Ascorbic Acid Blood Free Radical Scavengers Analysis Correlational Studies Cross Sectional Studies Human Aged Male Female Audiometry, Pure-Tone Chromatography, High Pressure Liquid Descriptive Statistics Spearman's Rank Correlation Coefficient Linear Regression Aged, 80 and Over Questionnaires Biological Assay Pilot Studies Data Analysis Software Aged: 65+ years Aged, 80 & over Male Female ab: Conclusion: Low plasma melatonin is significant in the development of high frequency hearing loss (HL) among the elderly. Objective: To determine the correlation between hearing threshold and the plasma melatonin and ascorbic acid (vitamin C). Methods: This was a cross-sectional study involving 126 apparently healthy elderly subjects, 59 males and 67 females, aged >60 years. Subjects underwent pure tone audiometry and plasma melatonin and vitamin C were assayed using high-performance liquid chromatography. Results: The mean ± SD of plasma melatonin among the subjects with normal hearing (NH) (0-30 dB) and those with HL in the speech frequencies was 18.3 ± 3.6 μg/L and 16.4 ± 4.7μg/L, respectively. In the high frequencies the values were 17.7 ± 6.2 μg/L and 13.1 ± 6.4μg/L for NH and HL, respectively. For vitamin C, the mean ± SD among subjects with NH and those with HL in the speech frequencies were 1.2 ± 0.2 μg/L and 1.0 ± 0.1 μg/L, respectively. In the high frequencies, the values were 1.0 ± 0.2 μg/L and 0.9 ± 0.3 μg/L for NH and HL, respectively. Among subjects with high frequency HL, Spearman's correlation revealed significant correlation between increasing hearing threshold and melatonin (correlation coefficient == -0.30, p == 0.01), but not for vitamin C (correlation coefficient == -0.12, p == 0.22). Linear regression, adjusting for age, still revealed significant correlation between the melatonin (correlation coefficient == -0.03, p == 0.00) and hearing threshold in the high frequencies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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