The place of implementation science in the translational medicine continuum.
There is a growing consensus that the transfer of knowledge from biomedical discoveries into patient and public benefit should be accelerated. At the same time there is a persistent lack of conceptual clarity about the precise nature of the phases of the translational continuum necessary to implemen...
| Publicado en: | Psychological Medicine Vol. 41; no. 10; pp. 2015 - 2022 |
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| Autores principales: | , , |
| Formato: | editorial Journal Article |
| Publicado: |
Cambridge University Press
Oct2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104706898&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104706898 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00332917 6Q3 jtl: Psychological Medicine issn: 00332917 maglogo: N pubinfo: dt: Oct2011 vid: 41 iid: 10 pid: 15979 pub: Cambridge University Press artinfo: ui: 104706898 66813450 10.1017/S0033291711000109 NLM21320391 104706898 ppf: 2015 ppct: 7 formats: tig: atl: The place of implementation science in the translational medicine continuum. aug: au: Thornicroft, G. Lempp, H. Tansella, M. affil: Health Service and Population Research Department, Institute of Psychiatry, King's College London, De Crespigny Park, London, UK sug: subj: Research, Medical Science Program Implementation Clinical Trials Communication ab: There is a growing consensus that the transfer of knowledge from biomedical discoveries into patient and public benefit should be accelerated. At the same time there is a persistent lack of conceptual clarity about the precise nature of the phases of the translational continuum necessary to implement this. In this paper, we: (i) propose an integrated schema to understand the five sequential phases that link basic biomedical research with clinical science and implementation; (ii) discuss the nature of three blocks along this translational pathway; (iii) outline key issues that need to be addressed in removing such barriers. The five research phases described are: (0) basic science discovery; (1) early human studies; (2) early clinical trials; (3) late clinical trials; (4) implementation (which includes adoption in principle, early implementation and persistence of implementation). This schema also sets out three points at which communication blocks can occur. The application of ‘implementation science’ is in its early stages within mental health and psychiatric research. This paper therefore aims to develop a consistent terminology to understand the discovery, development, dissemination and implementation of new interventions. By better understanding the factors that promote or delay knowledge to flow across these blocks, we can accelerate progression along translational medicine pathways and so realize earlier patient benefit. pubtype: Academic Journal doctype: editorial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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