Electrocardiographic ST-Segment Depression and Exposure to Traffic-Related Aerosols in Elderly Subjects with Coronary Artery Disease.
BACKGROUND: Air pollutants have not been associated with ambulatory electrocardiographic evidence of ST-segment depression 1 mm (probable cardiac ischemia). We previously found that markers of primary (combustion-related) organic aerosols and gases were positively associated with circulating biomark...
| Publicado en: | Environmental Health Perspectives Vol. 119; no. 2; pp. 196 - 203 |
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| Autores principales: | , , , , , , , |
| Formato: | equations & formulas research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Feb2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104709512&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104709512 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Feb2011 vid: 119 iid: 2 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104709512 60682901 10.1289/ehp.1002372 NLM20965803 PMC3040606 104709512 ppf: 196 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Electrocardiographic ST-Segment Depression and Exposure to Traffic-Related Aerosols in Elderly Subjects with Coronary Artery Disease. aug: au: Delfino, Ralph J. Gillen, Daniel L. Tjoa, Thomas Staimer, Norbert Polidori, Andrea Arhami, Mohammad Sioutas, Constantinos Longhurst, John affil: Department of Epidemiology, School of Medicine, University of California-Irvine, Irvine, California, USA sug: subj: Aerosols Adverse Effects Smog Adverse Effects ST Segment Coronary Arteriosclerosis Risk Factors Human Aged California Motor Vehicles Odds Ratio Confidence Intervals Diaries Environmental Exposure Poisson Distribution Data Analysis Software Physical Activity Funding Source Aged: 65+ years ab: BACKGROUND: Air pollutants have not been associated with ambulatory electrocardiographic evidence of ST-segment depression 1 mm (probable cardiac ischemia). We previously found that markers of primary (combustion-related) organic aerosols and gases were positively associated with circulating biomarkers of inflammation and ambulatory blood pressure in the present cohort panel study of elderly subjects with coronary artery disease. OBJECTIVES: We specifically aimed to evaluate whether exposure markers of primary organic aerosols and ultrafine particles were more strongly associated with ST-segment depression of ≥1 mm than were secondary organic aerosols or PM2.5 (particulate matter with aerodynamic diameter ≤ 2.5 μm) mass. METHODS: We evaluated relations of air pollutants to ambulatory electrocardiographic evidence of cardiac ischemia over 10 days in 38 subjects without ST depression on baseline electrocardiographs. Exposures were measured outdoors in retirement communities in the Los Angeles basin, including daily size-fractionated particle mass and hourly markers of primary and secondary organic aerosols and gases. Generalized estimating equations were used to estimate odds of hourly ST-segment depression (≥ 1 mm) from hourly air pollution exposures and to estimate relative rates of daily counts of ST-segment depression from daily average exposures, controlling for potential confounders. RESULTS: We found significant positive associations of hourly ST-segment depression with markers of combustion-related aerosols and gases averaged 1-hr through 3-4 days, but not secondary (photo- chemically aged) organic aerosols or ozone. The odds ratio per interquartile increase in 2-day average primary organic carbon (5.2 μg /m3) was 15.4 (95% confidence interval, 3.5-68.2). Daily counts of ST-segment depression were consistently associated with primary combustion markers and 2-day average quasi-ultrafine particles < 0.25 μm. CONCLUSIONS: Results suggest that exposure to quasi-ultrafine particles and combustion-related pollutants (predominantly from traffic) increase the risk of myocardial ischemia, coherent with our previous findings for systemic inflammation and blood pressure. pubtype: Academic Journal doctype: equations & formulas research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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