Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure.
BACKGROUND: Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes. OBJECTIVE: We examined the association between mean childhood blood lead levels and in vivo...
| Publicado en: | Environmental Health Perspectives Vol. 119; no. 3; pp. 403 - 409 |
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| Autores principales: | , , , , , , |
| Formato: | diagnostic images research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104709531&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104709531 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2011 vid: 119 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104709531 60689357 10.1289/ehp.1002176 NLM20947467 PMC3060006 104709531 ppf: 403 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Proton Magnetic Resonance Spectroscopy in Adults with Childhood Lead Exposure. aug: au: Cecil, Kim M. Dietrich, Kim N. Altaye, Mekibib Egelhoff, John C. Lindquist, Diana M. Brubaker, Christopher J. Lanphear, Bruce P. affil: Cincinnati Children's Environmental Health Center at Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Environmental Health, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA sug: subj: Lead Adverse Effects Environmental Exposure Magnetic Resonance Spectroscopy Brain Metabolism Environmental Health Human Child Young Adult Descriptive Statistics Multiple Linear Regression Lead Blood Aspartic Acid Metabolism Creatine Metabolism Glutamine Metabolism Brain Ultrasonography Prospective Studies Ohio Infant, Newborn Child, Preschool Adolescence Sample Size Self Report Prenatal Exposure Delayed Effects Magnetic Resonance Imaging Pearson's Correlation Coefficient Spearman's Rank Correlation Coefficient Child: 6-12 years Infant, Newborn: birth-1 month Child, Preschool: 2-5 years Adolescent: 13-18 years ab: BACKGROUND: Childhood lead exposure adversely affects neurodevelopment. However, few studies have examined changes in human brain metabolism that may underlie known adverse cognitive and behavioral outcomes. OBJECTIVE: We examined the association between mean childhood blood lead levels and in vivo brain metabolite concentrations as adults, determined by proton magnetic resonance spectroscopy (MRS) in a birth cohort with documented low-to-moderate lead exposure. METHODS: Adult participants from the Cincinnati Lead Study [n = 159; mean age (± SD), 20.8 ± 0.9 years] completed a quantitative, short-echo proton MRS protocol evaluating seven regions to determine brain concentrations of N-acetyl aspartate (NAA), creatine and phosphocreatine (Cr), cholines (Cho), myo-inositol, and a composite of glutamate and glutamine (GLX). Correlation and multiple linear regression analyses were conducted. RESULTS: Mean childhood blood lead levels were associated with regionally specific brain metabolite concentrations adjusted for age at imaging and Full-Scale intelligence quotient. Adjusted analyses estimated for a unit (micrograms per deciliter) increase in mean childhood blood lead concentrations, a decrease of NAA and Cr concentration levels in the basal ganglia, a decrease of NAA and a decrease of Cho concentration levels in the cerebellar hemisphere, a decrease of GLX concentration levels in vermis, a decrease of Cho and a decrease of GLX concentration levels in parietal white matter, and a decrease of Cho concentration levels in frontal white matter. CONCLUSIONS: Gray-matter NAA reductions associated with increasing childhood blood lead levels suggest that sustained childhood lead exposure produces an irreversible pattern of neuronal dysfunction, whereas associated white-matter choline declines indicate a permanent alteration to myelin architecture. pubtype: Academic Journal doctype: diagnostic images research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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