Utility of Recent Studies to Assess the National Research Council 2001 Estimates of Cancer Risk from Ingested Arsenic.
OBJECTIVE: The purpose of this review is to evaluate the impact of recent epidemiologic literature on the National Research Council (NRC) assessment of the lung and bladder cancer risks from ingesting low concentrations (< 100 μg/L) of arsenic-contaminated water. DATA SOURCES, EXTRACTION, AND SYNTHE...
| Published in: | Environmental Health Perspectives Vol. 119; no. 3; pp. 284 - 291 |
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| Main Authors: | , , , , , , , , , |
| Format: | research systematic review tables/charts Journal Article |
| Published: |
National Institute of Environmental Health Sciences
Mar2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104709542&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104709542 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2011 vid: 119 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104709542 60695030 10.1289/ehp.1002427 NLM21030336 PMC3059988 104709542 ppf: 284 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Utility of Recent Studies to Assess the National Research Council 2001 Estimates of Cancer Risk from Ingested Arsenic. aug: au: Gibb, Herman Haver, Cary Gaylor, David Ramasamy, Santhini Lee, Janice S. Lobdell, Danelle Wade, Timothy Chao Chen White, Paul Sams, Reeder affil: Tetra Tech Sciences, Arlington, Virginia, USA sug: subj: Risk Assessment Bladder Neoplasms Risk Factors Arsenic Adverse Effects Lung Neoplasms Risk Factors Environmental Exposure Human Systematic Review PubMed Taiwan Epidemiological Research Sample Size Water Relative Risk Confidence Intervals ab: OBJECTIVE: The purpose of this review is to evaluate the impact of recent epidemiologic literature on the National Research Council (NRC) assessment of the lung and bladder cancer risks from ingesting low concentrations (< 100 μg/L) of arsenic-contaminated water. DATA SOURCES, EXTRACTION, AND SYNTHESIS: PubMed was searched for epidemiologic studies pertinent to the lung and bladder cancer risk estimates from low-dose arsenic exposure. Articles published from 2001, the date of the NRC assessment, through September 2010 were included. Fourteen epidemiologic studies on lung and bladder cancer risk were identified as potentially useful for the analysis. CONCLUSIONS: Recent epidemiologic studies that have investigated the risk of lung and bladder cancer from low arsenic exposure are limited in their ability to detect the NRC estimates of excess risk because of sample size and less than lifetime exposure. Although the ecologic nature of the Taiwanese studies on which the NRC estimates are based present certain limitations, the data from these studies have particular strengths in that they describe lung and bladder cancer risks resulting from lifetime exposure in a large population and remain the best data on which to conduct quantitative risk assessment. Continued follow-up of a population in northeastern Taiwan, however, offers the best opportunity to improve the cancer risk assessment for arsenic in drinking water. Future studies of arsenic < 100 μg/L in drinking water and lung and bladder cancer should consider adequacy of the sample size, the synergistic relationship of arsenic and smoking, duration of arsenic exposure, age when exposure began and ended, and histologic subtype. pubtype: Academic Journal doctype: research systematic review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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