Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects before and after Drastic Weight Loss.
BACKGROUND: In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. OBJECTIVES: We characterized POP total body burden and their redistribution in obese individuals before an...
| Publicado en: | Environmental Health Perspectives Vol. 119; no. 3; pp. 377 - 384 |
|---|---|
| Autores principales: | , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
National Institute of Environmental Health Sciences
Mar2011
|
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104709548&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104709548 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00916765 3B5 jtl: Environmental Health Perspectives issn: 00916765 maglogo: N pubinfo: dt: Mar2011 vid: 119 iid: 3 pid: 56539 pub: National Institute of Environmental Health Sciences place: Research Triangle Park, North Carolina artinfo: ui: 104709548 60698311 10.1289/ehp.1002848 NLM21156398 PMC3060002 104709548 ppf: 377 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Fate and Complex Pathogenic Effects of Dioxins and Polychlorinated Biphenyls in Obese Subjects before and after Drastic Weight Loss. aug: au: Min-Ji Kim Marchand, Philippe Henegar, Corneliu Antignac, Jean-Philippe Alili, Rohia Poitou, Christine Bouillot, Jean-Luc Basdevant, Arnaud Le Bizec, Bruno Barouki, Robert Clément, Karine affil: INSERM, UMR-S 747, Université Paris Descartes, Centre Universitaire des Saints-Pères, Paris, France sug: subj: Polychlorinated Biphenyls Environmental Pollutants Weight Loss Obesity Human Obesity Surgery Comparative Studies Adipose Tissue Bariatric Surgery France Body Mass Index Absorptiometry, Photon Blood Analysis Gene Expression Wilcoxon Rank Sum Test Multivariate Analysis of Variance Factor Analysis Spearman's Rank Correlation Coefficient Data Analysis Software ab: BACKGROUND: In humans, persistent organic pollutants (POPs) are stored primarily in adipose tissue. Their total body burden and their contribution to obesity-associated diseases remain unclear. OBJECTIVES: We characterized POP total body burden and their redistribution in obese individuals before and after drastic weight loss and compared these values with a variety of molecular, biological, and clinical parameters. Methods: Seventy-one obese subjects were enrolled and underwent bariatric surgery. Blood and adipose tissue samples were obtained at different times from these individuals as well as from 18 lean women. RESULTS: POP content (17 dioxins/furans and 18 polychlorinated biphenyl congeners) in different adipose tissue territories was similar, allowing us to assess total POP body burden from a single biopsy. Total POP body burden was 2 to 3 times higher in obese than in lean individuals. We also found increased expression of some POP target genes in obese adipose tissue. Drastic weight loss led to increased serum POPs and, within 6-12 months, to a significant 15% decrease in total polychlorinated biphenyl body burden. Importantly, serum POP levels were positively correlated with liver toxicity markers and lipid parameters, independently of age and body mass index. CONCLUSIONS: POP content in adipose tissue and serum correlate with biological markers of obesity- related dysfunctions. Drastic weight loss leads to a redistribution of POPs and to a moderate decrease of their total body burden. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
|---|