Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation.
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten i...
| Publicado en: | Dermatologic Clinics Vol. 29; no. 3; pp. 469 - 478 |
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| Autores principales: | , |
| Formato: | Journal Article |
| Publicado: |
W B Saunders
2011 Jul
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104710410&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104710410 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07338635 DO3 jtl: Dermatologic Clinics issn: 07338635 maglogo: N pubinfo: dt: 2011 Jul vid: 29 iid: 3 pid: 1351 pub: W B Saunders place: Philadelphia, Pennsylvania artinfo: ui: 104710410 2011067581 10.1016/j.det.2011.03.005 NLM21605814 104710410 ppf: 469 ppct: 9 formats: tig: atl: Pathophysiology of dermatitis herpetiformis: a model for cutaneous manifestations of gastrointestinal inflammation. aug: au: Cardones AR Hall RP 3rd affil: Department of Dermatology, Duke University, DUMC 3135, Durham, NC 27710, USA. sug: subj: Immunity Immunology Skin Diseases, Vesiculobullous Immunology Skin Diseases, Vesiculobullous Physiopathology Gastroenteritis Immunology Gastroenteritis Physiopathology Autoantibodies Immunology Skin Diseases, Vesiculobullous Pathology Gastroenteritis Pathology Skin Skin Pathology Skin Physiopathology ab: Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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