Four-dimensional positron emission tomography: implications for dose painting of high-uptake regions.
Purpose: To investigate the behavior of tumor subvolumes of high [18F]-fluorodeoxyglucose (FDG) uptake as seen on clinical four-dimensional (4D) FDG-positron emission tomography (PET) scans. Methods and Materials: Four-dimensional FDG-PET/computed tomography scans from 13 patients taken before radio...
| Published in: | International Journal of Radiation Oncology, Biology, Physics Vol. 80; no. 3; pp. 900 - 909 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
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Pergamon Press - An Imprint of Elsevier Science
Jul2011
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104711508&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104711508 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 03603016 1ZQ jtl: International Journal of Radiation Oncology, Biology, Physics issn: 03603016 maglogo: N pubinfo: dt: Jul2011 vid: 80 iid: 3 pid: 2410 pub: Pergamon Press - An Imprint of Elsevier Science artinfo: ui: 104711508 NLM20950956 2011068828 10.1016/j.ijrobp.2010.08.028 NLM20950956 104711508 ppf: 900 ppct: 9 formats: tig: atl: Four-dimensional positron emission tomography: implications for dose painting of high-uptake regions. aug: au: Aristophanous M Yap JT Killoran JH Chen AB Berbeco RI Aristophanous, Michalis Yap, Jeffrey T Killoran, Joseph H Chen, Aileen B Berbeco, Ross I affil: Departments of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center and Harvard Medical School, Boston, MA 02115, USA sug: subj: Fludeoxyglucose F 18 Pharmacokinetics Lung Neoplasms Radiography Tomography, Emission-Computed Methods Radiopharmaceuticals Pharmacokinetics Adenocarcinoma Metabolism Adenocarcinoma Pathology Adenocarcinoma Radiography Adenocarcinoma Radiotherapy Aged Aged, 80 and Over Algorithms Carcinoma, Squamous Cell Metabolism Carcinoma, Squamous Cell Pathology Carcinoma, Squamous Cell Radiography Carcinoma, Squamous Cell Radiotherapy Female Fludeoxyglucose F 18 Diagnostic Use Lung Neoplasms Metabolism Lung Neoplasms Pathology Lung Neoplasms Radiotherapy Male Middle Age Radiopharmaceuticals Diagnostic Use Radiation Dosage Tomography, X-Ray Computed Methods Body Weights and Measures Aged: 65+ years Aged, 80 & over Middle Aged: 45-64 years Female Male ab: Purpose: To investigate the behavior of tumor subvolumes of high [18F]-fluorodeoxyglucose (FDG) uptake as seen on clinical four-dimensional (4D) FDG-positron emission tomography (PET) scans. Methods and Materials: Four-dimensional FDG-PET/computed tomography scans from 13 patients taken before radiotherapy were available. The analysis was focused on regions of high uptake that are potential dose-painting targets. A total of 17 lesions (primary tumors and lymph nodes) were analyzed. On each one of the five phases of the 4D scan a classification algorithm was applied to obtain the region of highest uptake and segment the tumor volume. We looked at the behavior of both the high-uptake subvolume, called "Boost," and the segmented tumor volume, called "Target." We measured several quantities that characterize the Target and Boost volumes and quantified correlations between them. Results: The behavior of the Target could not always predict the behavior of the Boost. The shape deformation of the Boost regions was on average 133% higher than that of the Target. The gross to internal target volume expansion was on average 27.4% for the Target and 64% for the Boost, a statistically significant difference (p < 0.05). Finally, the inhale-to-exhale phase (20%) had the highest shape deformation for the Boost regions. Conclusions: A complex relationship between the measured quantities for the Boost and Target volumes is revealed. The results suggest that in cases in which advanced therapy techniques such as dose painting are being used, a close examination of the 4D PET scan should be performed. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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