Coexistence of fatal disseminated invasive aspergillosis and pyoderma gangrenosum: a case report.
Objective: To report an unusual case of disseminated aspergillosis involving the lymph nodes, lungs, and skin in a patient with pyoderma gangrenosum (PG) and myelodysplastic syndrome (MDS).Case Presentation and Intervention: A 46-year-old man presented with productive cough of 2 weeks' duration. Bes...
| Publicado en: | Medical Principles & Practice Vol. 20; no. 4; pp. 380 - 384 |
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| Autores principales: | , , , |
| Formato: | case study research Journal Article |
| Publicado: |
Karger AG
2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104712480&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104712480 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10117571 NJW jtl: Medical Principles & Practice issn: 10117571 maglogo: N pubinfo: dt: 2011 vid: 20 iid: 4 pid: 2485 pub: Karger AG artinfo: ui: 104712480 104712480 NLM21577002 2011070570 10.1159/000324802 NLM21577002 104712480 ppf: 380 ppct: 4 formats: tig: atl: Coexistence of fatal disseminated invasive aspergillosis and pyoderma gangrenosum: a case report. aug: au: Yang, Chien-Chang Hsu, Po-Chang Cheng, Chun-Wen Lee, Ming-Hsun affil: Division of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan. sug: subj: Aspergillosis Complications Myelodysplastic Syndromes Complications Pyoderma Gangrenosum Complications Adrenal Cortex Hormones Adverse Effects Antifungal Agents Therapeutic Use Aspergillosis Diagnosis Aspergillosis Drug Therapy Aspergillosis Microbiology Peptides Therapeutic Use Fatal Outcome Male Middle Age Myelodysplastic Syndromes Diagnosis Myelodysplastic Syndromes Microbiology Myelodysplastic Syndromes Pathology Pyoderma Gangrenosum Diagnosis Pyoderma Gangrenosum Drug Therapy Pyoderma Gangrenosum Microbiology Middle Aged: 45-64 years Male ab: Objective: To report an unusual case of disseminated aspergillosis involving the lymph nodes, lungs, and skin in a patient with pyoderma gangrenosum (PG) and myelodysplastic syndrome (MDS).Case Presentation and Intervention: A 46-year-old man presented with productive cough of 2 weeks' duration. Besides, several painless, fixed lymph nodes were palpated at his left neck. He had PG and MDS diagnosed in June 2004 with regular use of oral dapsone and prednisolone. His skin lesions healed with scar formation and no purulent discharge. A computed tomography scan of the head, neck and chest showed bilateral lung consolidation and abscesses at the left neck, right upper lung and right pleura. The neck abscess culture grew Aspergillus species. Dark reddish macules developed over the right arm, chest and abdominal wall, and the left lower limb 2 weeks after initiation of amphotericin B. The histology of the right arm skin biopsy showed invasive aspergillosis. Caspofungin was started then for suspicion of poor response to amphotericin B. He expired despite 35 days of antifungal therapy.Conclusion: This report highlights the rarity of coexistence of disseminated aspergillosis and PG, and should alert physicians to the possibility of invasive fungal infection superimposed on a chronic skin lesion. pubtype: Academic Journal doctype: case study research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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