Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects.
Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man.Design: Latin square, randomized, double-blind, diet-controlled.Setting: Metabolic researc...
| Publicado en: | European Journal of Clinical Nutrition Vol. 53; no. 1; pp. 1 - 8 |
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| Autores principales: | , , , |
| Formato: | research randomized controlled trial Journal Article |
| Publicado: |
Springer Nature
Jan1999
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104714770&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104714770 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09543007 EUC jtl: European Journal of Clinical Nutrition issn: 09543007 maglogo: N pubinfo: dt: Jan1999 vid: 53 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 104714770 1532529 NLM10048793 2011072391 10.1038/sj.ejcn.1600668 NLM10048793 104714770 ppf: 1 ppct: 7 formats: tig: atl: Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects. aug: au: van Dokkum, W Wezendonk, B Srikumar, T S van den Heuvel, E G affil: TNO Nutrition and Food Research Institute, Zeist, The Netherlands. sug: subj: Dietary Fiber Metabolism Glucose Pharmacokinetics Intestine, Large Physiology Lipids Blood Oligosaccharides Metabolism Adult Blood Chemical Analysis Dietary Fiber Administration and Dosage Double-Blind Studies Eating Enzymes Analysis Feces Glucose Tolerance Test Glycoside Hydrolases Analysis Human Intestinal Absorption Male Oligosaccharides Administration and Dosage Questionnaires Randomized Controlled Trials Urease Analysis Adult: 19-44 years Male ab: Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man.Design: Latin square, randomized, double-blind, diet-controlled.Setting: Metabolic research unit.Subjects: Twelve apparently healthy men (mean age 23 years), recruited from the Institute's pool of volunteers, no drop-outs.Interventions: Four treatment periods of 3 weeks: inulin, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and control; analyses of stool weight, intestinal transit, faecal pH, short-chain fatty acids, bile acids, faecal enzymes, blood lipids and glucose absorption.Results: As compared to the control treatment: higher concentration of faecal acetate (inulin and GOS, P < 0.05) and valerate (inulin, P < 0.05), significantly lower concentration of faecal deoxycholic acid (inulin and FOS, P < 0.05 and P< 0.02, respectively) and beta-glucuronidase activity (inulin and GOS, P < 0.05 and P < 0.02 respectively). Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant.Conclusions: RESULTS indicate that nondigestible oligosaccharides are (partly) fermented in the human colon, but in healthy young men the effects are limited. Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults. pubtype: Academic Journal doctype: research randomized controlled trial Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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