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A study of bispectral analysis and auditory evoked potential indices during propofol-induced hypnosis in volunteers: the effect of an episode of wakefulness on explicit and implicit memory.

The bispectral index (BIS) and the auditory evoked potential (AEP) index as calculated by the new A-line monitor were measured during hypnosis with propofol, which included an episode of wakefulness. Both indices followed a similar pattern during sedation, with values decreasing with sedation and in...

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Published in:Anaesthesia Vol. 56; no. 9; pp. 888 - 894
Main Authors: Barr, G, Anderson, R E, Jakobsson, J G
Format: research Journal Article
Published: Wiley-Blackwell Sep2001
Online Access:View this record in EBSCOhost
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      dt: Sep2001
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      pub: Wiley-Blackwell
      place: Malden, Massachusetts
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        atl: A study of bispectral analysis and auditory evoked potential indices during propofol-induced hypnosis in volunteers: the effect of an episode of wakefulness on explicit and implicit memory.
      aug:
        au:
          Barr, G
          Anderson, R E
          Jakobsson, J G
        affil: Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
      sug:
        subj:
          Anesthetics, Intravenous Pharmacodynamics
          Electroencephalography
          Evoked Potentials, Auditory Drug Effects
          Intraoperative Monitoring Methods
          Propofol Pharmacodynamics
          Adult
          Clinical Assessment Tools
          Consciousness Drug Effects
          Female
          Male
          Memory Drug Effects
          Middle Age
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: The bispectral index (BIS) and the auditory evoked potential (AEP) index as calculated by the new A-line monitor were measured during hypnosis with propofol, which included an episode of wakefulness. Both indices followed a similar pattern during sedation, with values decreasing with sedation and increasing when awake. Baseline AEP values varied between 60 and 98, and BIS values were between 96 and 98. The AEP-index value was at all times 10-20 points lower than the BIS-index. The transition to loss of response occurred at a mean AEP value of 46 and BIS value of 58. The transition to just responding following a period of unconsciousness occurred at a mean AEP value of 46 and BIS 65. Both monitoring techniques, however, displayed large interindividual variations making it impossible to discriminate in real time between subtle changes of clinical state. The new neurophysiological monitors A-line AEP and BIS are interesting tools for creating a better understanding of the anaesthetic effects of drugs; however, further refinements are required before their relative roles can be fully established in the clinical setting.
      pubtype: Academic Journal
      doctype:
        research
        Journal Article
      ougenre: Article
    language: English
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