Impaired explicit memory after recovery from propofol/sufentanil anaesthesia is related to changes in the midlatency auditory evoked response.

Background: Midlatency auditory evoked responses (MLAER) can distinguish different stages of anaesthesia. We studied MLAER during emergence from propofol/sufentanil anaesthesia in relation to recovery of explicit memory.Methods: MLAER were recorded in 29 healthy patients before and during anaesthesi...

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Publicado en:BJA: The British Journal of Anaesthesia Vol. 89; no. 3; pp. 376 - 382
Autores principales: Rundshagen, I, Schnabel, K, Schulte am Esch, J
Formato: Journal Article
Publicado: Elsevier B.V. Sep2002
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Sep2002
      vid: 89
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      pub: Elsevier B.V.
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        atl: Impaired explicit memory after recovery from propofol/sufentanil anaesthesia is related to changes in the midlatency auditory evoked response.
      aug:
        au:
          Rundshagen, I
          Schnabel, K
          Schulte am Esch, J
        affil: Department of Anaesthesiology, University Hospital Charité, Campus Charité Mitte, Schumannstrasse 20/21, D-10117 Berlin, Germany.
      sug:
        subj:
          Anesthetics, Intravenous
          Evoked Potentials, Auditory Physiology
          Memory
          Propofol
          Sufentanil
          Adolescence
          Adult
          Brain Stem Physiology
          Female
          Male
          Middle Age
          Time Factors
          Adolescent: 13-18 years
          Adult: 19-44 years
          Middle Aged: 45-64 years
          Female
          Male
      ab: Background: Midlatency auditory evoked responses (MLAER) can distinguish different stages of anaesthesia. We studied MLAER during emergence from propofol/sufentanil anaesthesia in relation to recovery of explicit memory.Methods: MLAER were recorded in 29 healthy patients before and during anaesthesia and during emergence until the patients opened their eyes spontaneously. After a structured interview the next day, patients were classified into those with and without explicit memory of the recovery period. Latencies Na, Pa and Nb and the peak-to-peak amplitudes NaPa and PaNb were compared between the groups by multivariate analysis of variance. Results are mean (SD).Results: At eye opening (37 (12) min after the end of anaesthesia) the latency Nb (47 (5) compared with 41 (5) ms; P < 0.001) was prolonged and the amplitude PaNb (1.3 (0.8) compared with I (0.5) ms; P = 0.012) was greater than the baseline value, respectively. The Nb latency was significantly shorter in patients with explicit memory (49 (2) ms compared with 45 (I); P = 0.041).Conclusions: Large intra- and inter-individual variability in the MLAER values limited their ability to predict memory responses in individual patients during emergence from propofol/sufentanil anaesthesia.
      pubtype: Academic Journal
      doctype: Journal Article
      ougenre: Article
    language: English
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