Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation.

The analgesic effect and adverse events of the weak opioid codeine is assumed to be mediated by its metabolite morphine. The cytochrome P-450 enzyme CYP2D6 catalysing the formation of morphine exhibits a genetic polymorphism. Two distinct phenotypes, the extensive (EMs) and poor metabolisers (PMs),...

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Bibliographic Details

Published in:	PAIN Vol. 76; no. 1-2; pp. 27 - 34
Main Authors:	Eckhardt, K, Li, S, Ammon, S, Schänzle, G, Mikus, G, Eichelbaum, M
Format:	clinical trial research Journal Article
Published:	Lippincott Williams & Wilkins 1998 May
Online Access:	View this record in EBSCOhost