Regional contraction of brain surface area involves three large-scale networks in schizophrenia.
In schizophrenia, morphological changes in the cerebral cortex have been primarily investigated using volumetric or cortical thickness measurements. In healthy subjects, as the brain size increases, the surface area expands disproportionately when compared to the scaling of cortical thickness. In th...
| Publicado en: | Schizophrenia Research Vol. 129; no. 2/3; pp. 163 - 169 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Elsevier B.V.
Jul2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104806289&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104806289 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 09209964 3PT jtl: Schizophrenia Research issn: 09209964 maglogo: N pubinfo: dt: Jul2011 vid: 129 iid: 2/3 pid: 1004 pub: Elsevier B.V. artinfo: ui: 104806289 NLM21497489 2011169334 10.1016/j.schres.2011.03.020 NLM21497489 104806289 ppf: 163 ppct: 6 formats: tig: atl: Regional contraction of brain surface area involves three large-scale networks in schizophrenia. aug: au: Palaniyappan L Mallikarjun P Joseph V White TP Liddle PF Palaniyappan, Lena Mallikarjun, Pavan Joseph, Verghese White, Thomas P Liddle, Peter F affil: Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom sug: subj: Brain Pathology Brain Mapping Schizophrenia Adolescence Adult Analysis of Variance Female Dominance, Cerebral Image Processing, Computer Assisted Magnetic Resonance Imaging Male Middle Age Young Adult Adolescent: 13-18 years Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: In schizophrenia, morphological changes in the cerebral cortex have been primarily investigated using volumetric or cortical thickness measurements. In healthy subjects, as the brain size increases, the surface area expands disproportionately when compared to the scaling of cortical thickness. In this structural MRI study, we investigated the changes in brain surface area in schizophrenia by constructing relative areal contraction/expansion maps showing group differences in surface area using Freesurfer software in 57 patients and 41 controls. We observed relative areal contraction affecting Default Mode Network, Central Executive Network and Salience Network, in addition to other regions in schizophrenia. We confirmed the surface area reduction across these three large-scale brain networks by undertaking further region-of-interest analysis of surface area. We also observed a significant hemispheric asymmetry in the surface area changes, with the left hemisphere showing a greater reduction in the areal contraction maps. Our findings suggest that a fundamental disturbance in cortical expansion is likely in individuals who develop schizophrenia. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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