Topography of gastritis and its severity in 864 first degree relatives of gastric cancer patients.
OBJECTIVES: Studies on gastric mucosal histological findings among first degree relatives (FDR) of gastric cancer (GC) patients are scarce. The aim is to evaluate the topography and the severity of gastritis among FDR of GC patients. DESIGN: A total of 989 subjects who were FDR of GC patients, ages...
| Publicado en: | Archives of Iranian Medicine (AIM) Vol. 13; no. 6; pp. 469 - 476 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Academy of Medical Sciences of I.R. Iran
Nov2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104808646&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104808646 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10292977 5DHN jtl: Archives of Iranian Medicine (AIM) issn: 10292977 maglogo: N pubinfo: dt: Nov2010 vid: 13 iid: 6 pid: 42042 pub: Academy of Medical Sciences of I.R. Iran place: , <Blank> artinfo: ui: 104808646 104808646 2010931506 NLM21039000 104808646 ppf: 469 ppct: 7 formats: tig: atl: Topography of gastritis and its severity in 864 first degree relatives of gastric cancer patients. aug: au: Zendehdel, Nasrin Massarrat, Sadegh Sheykholeslami, Arghavan Rakhshani, Naser Saeidi, Sandra Rafiee, Reza Nobakht, Hosein Tabib, Seyed Masoud Saliminejhad, Mehrdad Dooghaie Moghadam, Masoud Nasiri, Jafar Azimi, Kourosh Fakhar, Reza Babaei, Mehdi Didehvar, Reza Mohammadi, Nosratollah Tavazoee, Mehdi Malekzadeh, Reza affil: Department of Internal Medicine, Shohada Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran. sug: subj: Family Gastritis Epidemiology Stomach Neoplasms Familial and Genetic Adult Aged Chi Square Test Data Analysis Software Female Gastritis Complications Gastritis Pathology Helicobacter Infections Complications Helicobacter Infections Epidemiology Helicobacter Pylori Human Iran Male Middle Age Precancerous Conditions Familial and Genetic Severity of Illness Stomach Neoplasms Etiology T-Tests Adult: 19-44 years Aged: 65+ years Middle Aged: 45-64 years Female Male ab: OBJECTIVES: Studies on gastric mucosal histological findings among first degree relatives (FDR) of gastric cancer (GC) patients are scarce. The aim is to evaluate the topography and the severity of gastritis among FDR of GC patients. DESIGN: A total of 989 subjects who were FDR of GC patients, ages 40-65 years underwent gastroscopies. When no gross lesion was found, five specimens were evaluated according to the Sydney Classification and one for urease testing in order to determine the type of gastritis and its severity. RESULTS: Of the 989 subjects, 107 had significant lesions, including two with GC and one with esophageal cancer. The 864 subjects who had complete morphological data taken from five gastric areas (two from the antrum and three from the corpus) comprised 419 males (mean age 48.5±7 years) and 445 females (mean age 47±6.4 years). The H. pylori rate was 76.6%. Normal mucosa was seen in 6.9%, antrum-restricted gastritis in 7.4%, antrum-predominant gastritis in 63.5% and corpus-predominant gastritis in 20% (both had >80% H. pylori infection) and corpus-restricted gastritis in 2%. More atrophy was seen in the antrum and corpus of FDR females than males. The severity did not differ between those with one or more GC patients' relatives. Forty-nine percent of FDR had atrophy and 9.4% intestinal metaplasia (IM) in the corpus. After the age of 40, there was progression of intestinal metaplasia from 12.2 to 27.3% in the antrum and from 6.7% to 26.2% in the corpus during two decades. No high grade dysplasia was found in this mid-age population. CONCLUSION: Only one-fifth of FDR have H. pylori-induced corpus-predominant gastritis who are at risk for cancer and suitable for eradication. Corpus-restricted gastritis is a rare disease in this area. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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