Serum interleukin-6 and adiponectin levels in patients with active or inactive Behçet's disease.
Objective: Behçet's disease (BD) is a chronic systemic inflammatory disease and its etiopathogenesis still remains unknown. Cytokines play a role in immune response and inflammatory reactions. The aim of this study is to determine the levels of proinflammatory cytokine interleukin-6 (IL-6) and anti-...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 1837 - 1845 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Dec2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104812767&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104812767 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Dec2010 vid: 30 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104812767 2010937906 10.5336/medsci.2009-15065 104812767 ppf: 1837 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Serum interleukin-6 and adiponectin levels in patients with active or inactive Behçet's disease. aug: au: Etem, Arzu Turkmen Yildirmak, Sembol Önalan, Ebru Etem Baran, Gehmi Seval, Hatice Koldas, Macir Cakmak, Mustafa Gurel, Mehmet Salih Yenice, Necati affil: Departments of Medical Biochemistry, Dermatology, Internal Medicine, Okmeydani Educational and Research Hospital sug: subj: Adiponectin Blood Behcet's Syndrome Physiopathology Interleukins Blood Adult Analysis of Variance Biological Markers Blood Sedimentation C-Reactive Protein Blood Case Control Studies Cholesterol Blood Data Analysis Software Descriptive Statistics Enzyme-Linked Immunosorbent Assay Female Human Leukocyte Count Lipoproteins, HDL Blood Male Mann-Whitney U Test Middle Age Pearson's Correlation Coefficient Post Hoc Analysis T-Tests Triglycerides Blood Wilcoxon Rank Sum Test Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: Behçet's disease (BD) is a chronic systemic inflammatory disease and its etiopathogenesis still remains unknown. Cytokines play a role in immune response and inflammatory reactions. The aim of this study is to determine the levels of proinflammatory cytokine interleukin-6 (IL-6) and anti-inflammatory cytokine adiponectin in the sera of patients with BD and to assess their importance as biological markers for disease activity. Material and Methods: Forty-four BD patients [19 males, 25 females, age: 35.65 ± 10.84 yrs (mean ± standart deviation) (SD)] and 25 healthy controls (10 males, 15 females, age: 29.80 ± 8.20 yrs) were included in the study. Patients were divided into active or inactive groups according to their clinical and laboratory findings (active, n= 21; inactive, n= 23). We determined serum IL-6 levels using the chemiluminescence method, and serum adiponectin levels by ELISA method. Results were expressed as mean ± standard error (SE). Results: Serum levels of IL-6 and adiponectin in BD patients (n= 44) (5.24 ± 0.84 pg/mL; 22.31 ± 1.71 µg/mL, respectively) were similar to the control group (n= 25) (4.59 ± 1.01 pg/mL; 21.68 ± 1.91 µg/mL, respectively). No significant difference was found in IL-6 and adiponectin levels between the active (n= 21), inactive (n= 23) and control (n= 25) groups. Conclusion: In parallel with the presence of inflammation and increased CRP, erythrocyte sedimentation rate and white blood cell count, higher IL-6 and lower adiponectin levels were expected in active BD patients compared to the controls. However, they were found to be similar in all groups. We conclude that ongoing anti-inflammatory treatment should be taken into consideration while interpreting the cytokine levels in these patients. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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