Serum neuron-specific enolase (NSE) and hemocysteine levels in obstructive sleep apnea syndrome (OSAS)
Objective: Presence of a biochemical marker of cerebral injury would be of great benefit in obstructive sleep apnea syndrome (OSAS) to screen for even small brain damage and to monitor efficacy of therapy. The aim of this study was to evaluate whether two different parameters in serum, neuron-specif...
| Published in: | Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 1884 - 1891 |
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| Main Authors: | , , , , , , , , |
| Format: | research tables/charts Journal Article |
| Published: |
Turkiye Klinikleri
Dec2010
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104812776&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104812776 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Dec2010 vid: 30 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104812776 104812776 2010937916 10.5336/medsci.2009-13868 104812776 ppf: 1884 ppct: 7 formats: fmt: @attributes: type: P tig: atl: Serum neuron-specific enolase (NSE) and hemocysteine levels in obstructive sleep apnea syndrome (OSAS) aug: au: Ergün, Pinar Çiftçi, Bülent Ergün, Rüçhan Erdogan, Yurdanur Turay, Ülkü Yilmaz Biber, Çigdem Firat, Selma Yilmaz, Aydin Gezici, Ali Riza affil: Ataturk Chest Diseases and Chest Surgery Center, Department of Chest Diseasess, Gazi University Faculty of Medicine, Ankara sug: subj: Enzymes Blood Homocysteine Blood Sleep Apnea Syndromes Physiopathology Adult Biological Markers Body Mass Index Brain Injuries Diagnosis Case Control Studies Chi Square Test Data Analysis Software Descriptive Statistics Female Fisher's Exact Test Human Male Mann-Whitney U Test Middle Age Polysomnography Spearman's Rank Correlation Coefficient Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: Presence of a biochemical marker of cerebral injury would be of great benefit in obstructive sleep apnea syndrome (OSAS) to screen for even small brain damage and to monitor efficacy of therapy. The aim of this study was to evaluate whether two different parameters in serum, neuron-specific enolase (NSE) and homocysteine, can be used to detect even subtle levels of cerebral injury in OSAS patients. Material and Methods: We studied 38 patients with OSAS and 30 control subjects with an apnea-hypopnea index (AHI) less than five events per hour. All were evaluated by full-night polysomnography, and in the following morning, serum levels of NSE and homocysteine levels were measured using standard techniques. Results: The AHI in OSAS group was 39.2 ± 13.8 (mean ± SD) AH/h. Serum NSE levels were significantly higher in OSAS group (12.3 ± 5.0 ng/ml) than in the control group (8.2 ± 1.9 ng/ml; p< 0.01). No significant difference was detected between the groups with regard to serum homocysteine levels (14.1 ± 6.3 v 14.6 ± 4.8 ?mol/L; p> 0.05). Conclusion: Elevated serum NSE levels were much more correlated with the severity of OSAS, whereas homocysteine levels were in normal range in these OSAS cases who were otherwise healthy. We believe that there is a need for more sensitive biochemical markers and methods for detecting small cerebral injury in patients with sleep apnea syndrome. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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