Efficacy of a single dose transdermal flurbiprofen administration in patients with knee osteoarthritis.
Objective: Nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely prescribed agents in osteoarthritis patients, and may lead to important side-effects which increase the risk of hospitalization and death. Transdermal administration of NSAIDs can provide relief of pain locally with re...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 1911 - 1917 |
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| Autores principales: | , , , , , , |
| Formato: | clinical trial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Dec2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104812784&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104812784 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Dec2010 vid: 30 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104812784 2010937925 10.5336/medsci.2008-9739 104812784 ppf: 1911 ppct: 6 formats: fmt: @attributes: type: P tig: atl: Efficacy of a single dose transdermal flurbiprofen administration in patients with knee osteoarthritis. aug: au: Tosun, Aliye Beyazova, Mehmet Meray, Jale Tirnaksiz, Figen Tuncel, Ethem Agabeyoglu, Ilbeyi Güler, Nesrin affil: Clinical of Physical Medicine and Rehabilitation Ankara Atatürk Education and Research Hospital sug: subj: Antiinflammatory Agents, Non-Steroidal Therapeutic Use Osteoarthritis, Knee Drug Therapy Transdermal Patches, Drugs Adult Data Analysis Software Descriptive Statistics Double-Blind Studies Dynamometry Female Hamstring Muscles Physiology Human Male Middle Age Muscle Strength Power Analysis Quadriceps Muscles Physiology T-Tests Torque Visual Analog Scaling Adult: 19-44 years Middle Aged: 45-64 years Female Male ab: Objective: Nonsteroidal anti-inflammatory drugs (NSAID) are among the most widely prescribed agents in osteoarthritis patients, and may lead to important side-effects which increase the risk of hospitalization and death. Transdermal administration of NSAIDs can provide relief of pain locally with relatively less side effects. This study was aimed to evaluate the efficacy of a single administration of 40 mg transdermal flurbiprofen on pain and on strength of quadriceps and hamstring muscles in patients with knee osteoarthritis. Material and Methods: This study is a double blind, placebo-controlled cross-over preliminary study. Transdermal flurbiprofen and placebo patches were administered to the 24 patients with knee osteoarthritis. Knee pain was evaluated using a visual analog scale (VAS) and the strength of quadriceps and hamstring muscles using an isokinetic dynamometer. Results: Mean VAS scores reduced from 5.3 ± 1.7 to 4.7 ± 1.6 (p= 0.88) after placebo administration, and from 5.4 ± 1.9 to 3.9 ± 1.7 (p= 0.04) following flurbiprofen administration. Peak torque and total work values of flexor and extensor muscles of knee did not differ statistically after flurbiprofen or placebo administrations. Conclusion: Pain significantly reduced after single dose of transdermal flurbiprofen patch. However, no significant difference in isokinetic assessment parameters was observed in the present study. To assess the effects of transdermal flurbiprofen and its efficacy on knee pain and function, further controlled studies in larger groups of patients with different doses of flurbiprofen are recommended. pubtype: Academic Journal doctype: clinical trial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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