Age related ultrastructural changes in corneal structure with respect to gender.
Objective: It is well known that gender plays an important role in sensitivity to various drugs, in the etiology and onset of certain diseases and it is one of the main causes leading to structural changes in various tissues. The degenerative effects of aging on some organs may vary in both sexes as...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 1979 - 1987 |
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| Autores principales: | , , , |
| Formato: | pictorial research tables/charts Journal Article |
| Publicado: |
Turkiye Klinikleri
Dec2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104812802&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104812802 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Dec2010 vid: 30 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104812802 2010937946 10.5336/medsci.2009-14499 104812802 ppf: 1979 ppct: 8 formats: fmt: @attributes: type: P tig: atl: Age related ultrastructural changes in corneal structure with respect to gender. aug: au: Karabay, Gulten Pelin, Can Zagyapan, Ragiba Ögüs, Ersin affil: Departments of Histology and Embryology, Anatomy, Biostatistics, Baskent University Faculty of Medicine, Ankara sug: subj: Cornea Anatomy and Histology Sex Factors Aging Animal Studies Female Male Models, Biological Rats Female Male ab: Objective: It is well known that gender plays an important role in sensitivity to various drugs, in the etiology and onset of certain diseases and it is one of the main causes leading to structural changes in various tissues. The degenerative effects of aging on some organs may vary in both sexes as well. Cornea is susceptible to the degenerative effects of aging leading to impairment of vision. The aim of the present study is to determine the effects of aging on the structure of endothelial and epithelial layers of cornea comparatively in both sexes. Material and Methods: In the present study, 14 male and 14 female Sprague-Dawley rats have been used. The control group was composed of 10-week-old male (n= 4) and female (n= 4) rats, and the older group was composed of 19-month-old male (n= 10) and female (n= 10) rats. Cornea samples were processed using the routine technique for transmission electron microscopical examination. Results: In the control group it was observed that the epithelial and endothelial layers of the cornea had a normal structure in both sexes. On the other hand, significant degenerative changes in the epithelial layer were detected in the older male group when compared to older female rats (p< 0.05). Distinct degenerative changes were also observed in the endothelial layer in both sexes, however there was no statistically significant difference between the sexes. Conclusion: In the present study it has been shown that aging causes changes in epithelial and endothelial layers of the cornea in both sexes, however the detrimental changes in the corneal epithelium is more significant in older males. pubtype: Academic Journal doctype: pictorial research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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