Recurrent gastrointestinal bleeding, intraabdominal abscesses and synchronous candidemia and meningitis due to leflunomide therapy: case report.
Leflunomide is a tumor necrosis factor-? (TNF-?) blocking agent which is commonly used in the management of rheumatoid arthritis (RA). We report a suspected case of leflunomide-induced recurrent gastrointestinal bleeding, intraabdominal abscesses with synchronous candidemia and then meningitis. A 63...
| Publicado en: | Turkiye Klinikleri Journal of Medical Sciences Vol. 30; no. 6; pp. 2027 - 2031 |
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| Autores principales: | , , , , |
| Formato: | case study Journal Article |
| Publicado: |
Turkiye Klinikleri
Dec2010
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104812853&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104812853 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 13000292 1VOP jtl: Turkiye Klinikleri Journal of Medical Sciences issn: 13000292 maglogo: N pubinfo: dt: Dec2010 vid: 30 iid: 6 pid: 67298 pub: Turkiye Klinikleri artinfo: ui: 104812853 2010937997 10.5336/medsci.2008-10268 104812853 ppf: 2027 ppct: 4 formats: fmt: @attributes: type: P tig: atl: Recurrent gastrointestinal bleeding, intraabdominal abscesses and synchronous candidemia and meningitis due to leflunomide therapy: case report. aug: au: Turhan, Vedat Acar, Ali Coban, Mehmet Öncul, Oral Çavuslu, Saban affil: Department of Infection Diseases and Clinic Microbiology GATA Haydarpasa Educational Hospital I.stanbul sug: subj: Abdomen Pathology Abscess Candidiasis Complications Enzyme Inhibitors Adverse Effects Gastrointestinal Hemorrhage Complications Meningitis Chemically Induced Recurrence Male Middle Age Middle Aged: 45-64 years Male ab: Leflunomide is a tumor necrosis factor-? (TNF-?) blocking agent which is commonly used in the management of rheumatoid arthritis (RA). We report a suspected case of leflunomide-induced recurrent gastrointestinal bleeding, intraabdominal abscesses with synchronous candidemia and then meningitis. A 63-year-old man was admitted to our Emergency Department with fever, mental confusion, and urinary incontinence. He had been used anticoagulants for ten years because of atrial fibrillation and leflunomide for two years because of RA. A history of two gastrointestinal bleeding attacks, intraabdominal abscess and candidemia during the leflunomide therapy had been documented. We diagnosed meningitis together with intraabdominal abscess, gastrointestinal bleeding, and candidemia in the third hospitalization of the patient. Leflunomide was discontinued, and the patient was treated with antimicrobials (antifungal and antibacterial) and surgical procedures consisting of drainage and resection of the intrabdominal abscess. Symptoms and signs of the patient were improved and he was discharged on the 25th day of hospitalization. There was no recurrence in following six months period. Leflunomide should be started after very strict evaluations to indicated patient. These evaluations should be focused on primarily tendency to bleeding especially in oral anticoagulant users and possible infectious complications of community acquired or nosocomial originated. pubtype: Academic Journal doctype: case study Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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