EGFR gene overexpression retained in an invasive xenograft model by solid orthotopic transplantation of human glioblastoma multiforme into nude mice.
Orthotopic xenograft animal model from human glioblastoma multiforme (GBM) cell lines often do not recapitulate an extremely important aspect of invasive growth and epidermal growth factor receptor (EGFR) gene overexpression of human GBM. We developed an orthotopic xenograft model by solid transplan...
| Publicado en: | Cancer Investigation Vol. 29; no. 3; pp. 229 - 240 |
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| Autores principales: | , , , , , |
| Formato: | research Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2011
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=104817765&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 104817765 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07357907 KU6 jtl: Cancer Investigation issn: 07357907 maglogo: Y pubinfo: dt: Mar2011 vid: 29 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 104817765 104817765 NLM21314332 2010941931 10.3109/07357907.2010.550665 NLM21314332 PMC3055715 104817765 ppf: 229 ppct: 11 formats: tig: atl: EGFR gene overexpression retained in an invasive xenograft model by solid orthotopic transplantation of human glioblastoma multiforme into nude mice. aug: au: Yi D Hua TX Lin HY Yi, Diao Hua, Tian Xin Lin, Huang Yan affil: Neurosurgical Department of Affiliated Zhongshan Hospital, Xiamen University, Xiamen, China sug: subj: Brain Neoplasms Models, Biological Genes Glioma Animals Blotting, Western Brain Neoplasms Pathology Gene Expression Gene Expression Profiling Glioma Pathology Immunohistochemistry Mice Reverse Transcriptase Polymerase Chain Reaction Xenografts Biochemical Phenomena ab: Orthotopic xenograft animal model from human glioblastoma multiforme (GBM) cell lines often do not recapitulate an extremely important aspect of invasive growth and epidermal growth factor receptor (EGFR) gene overexpression of human GBM. We developed an orthotopic xenograft model by solid transplantation of human GBM into the brain of nude mouse. The orthotopic xenografts sharing the same histopathological features with their original human GBMs were highly invasive and retained the overexpression of EGFR gene. The murine orthotopic GBM models constitute a valuable in vivo system for preclinical studies to test novel therapies for human GBM. pubtype: Academic Journal doctype: research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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